The asymmetric dihydroxylation of drim-7-en-11-ol was studied in detail and diastereomerically pure driman-7α,8α,11- and driman-7β, 8β,11-triols were prepared. Further elaboration of driman-7α, 8α,11-triol afforded 14,15-bisnorlabd-7α,8α- isopropylidenedioxy-11,13-dione from which a novel chlorinated bisnorlabdanic compound (14,15-bisnorlabd-12-ene-12-chloro-8α,13-epoxy-7α-ol-11- one) and an unusual dichloro-derivative, 13,14,15,16-tetranorlabd-12-dichloro- 7α-acetoxy-8α-ol-11-one, were obtained.
|Titolo:||Asymmetric dihydroxylation of drim-7-en-11-ol: synthesis of diastereomerically pure driman-7α,8α,11-triol and its elaboration into novel chlorinated norlabdanic compounds|
GORINCIOI, ELENA (Secondo)
SANTANIELLO, ENZO (Ultimo)
|Settore Scientifico Disciplinare:||Settore BIO/10 - Biochimica|
|Data di pubblicazione:||2010|
|Digital Object Identifier (DOI):||10.16/j.tetasy.2010.06.029|
|Appare nelle tipologie:||01 - Articolo su periodico|