Introduction: We retrospectively reviewed a large group of CD5 negative chronic B-cell lymphoid leukemias (B-CLL), a group of disorders relatively uncommon, poorly described, heterogeneous from a biologic, cyto-morphologic and clinical point of view, and whose histo-pathological definition is often missing for absence of lymph adenopathy. Methods: 156 patients affected by CD5-CD10 negative B-CLL (median age 66; 39-86), were evaluated for clinico-hematological features at diagnosis, follow-up and overall survival; variables related to prognosis were identified. Hairy cell leukemias and large cell lymphomas in leukemic phase were excluded. Results: Median follow-up was 51 months (range 12-216). Overall survival at 3 and 5 yrs was 87% and 76%; 50 patients needed therapy at diagnosis and 40 during follow-up (3-117 months). Bulky disease, B symptoms, anemia (Hb <11g/dl), albumin and LDH levels and lymphocytosis degree significantly related with treatment starting at diagnosis. Patients without organ involvement had a borderline significant better survival. At multivariate analysis, LDH levels (P=0.001) and age >60 yrs (P=0.007) were significantly related to overall survival, and LDH (P<0.001), haemoglobin (P=0.007) and systemic clinical presentation (P=0.002) to time to failure (defined as need of therapy for the indolent cases and relapse/progression for treated cases). Conclusions: This retrospective study describes the clinical features and the variables related to evolution in a large cohort of patients with CD5 negative chronic B-cell lymphoid leukemias.

A polycentric study ON CD5 negative chronic B cell leukemias / M. Goldaniga, A. Ferrario, S. Cortelazzo, A. Guffanti, E. Pavone, A. Ambrosetti, L. Marcheselli, S. Luminari, A. Rossi, L. Baldini. - In: ANNALS OF ONCOLOGY. - ISSN 0923-7534. - 16:suppl. 5(2005 Jun), pp. v90-v90. ((Intervento presentato al 9. convegno International Conference on Malignant Lymphoma-ICML tenutosi a Lugano nel 2005 [10.1093/annonc/mdi564].

A polycentric study ON CD5 negative chronic B cell leukemias

A. Ferrario;L. Baldini
2005-06

Abstract

Introduction: We retrospectively reviewed a large group of CD5 negative chronic B-cell lymphoid leukemias (B-CLL), a group of disorders relatively uncommon, poorly described, heterogeneous from a biologic, cyto-morphologic and clinical point of view, and whose histo-pathological definition is often missing for absence of lymph adenopathy. Methods: 156 patients affected by CD5-CD10 negative B-CLL (median age 66; 39-86), were evaluated for clinico-hematological features at diagnosis, follow-up and overall survival; variables related to prognosis were identified. Hairy cell leukemias and large cell lymphomas in leukemic phase were excluded. Results: Median follow-up was 51 months (range 12-216). Overall survival at 3 and 5 yrs was 87% and 76%; 50 patients needed therapy at diagnosis and 40 during follow-up (3-117 months). Bulky disease, B symptoms, anemia (Hb <11g/dl), albumin and LDH levels and lymphocytosis degree significantly related with treatment starting at diagnosis. Patients without organ involvement had a borderline significant better survival. At multivariate analysis, LDH levels (P=0.001) and age >60 yrs (P=0.007) were significantly related to overall survival, and LDH (P<0.001), haemoglobin (P=0.007) and systemic clinical presentation (P=0.002) to time to failure (defined as need of therapy for the indolent cases and relapse/progression for treated cases). Conclusions: This retrospective study describes the clinical features and the variables related to evolution in a large cohort of patients with CD5 negative chronic B-cell lymphoid leukemias.
Settore MED/15 - Malattie del Sangue
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/148821
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