In the medicinal chemistry field, peptides represent probably one of the most important class of compounds for many reasons. The great range of biological applications connected to the natural activity of some of these compounds is so important that makes peptides a primary target in the scientific research. However, syntheses and studies of peptidic structures are sometimes very complicated, cause their molecular complexity and metabolic stability. For these reasons, recent research is focused on the realization of simpler products such as peptidomimetics, which are designed to preserve the same therapeutics proprieties of natural peptides, but with the advantage of a better metabolic stability and of a easier conservation of the bioactive conformation. One of the common feature to all peptidomimetic compounds is the rigid backbone which improve the biological activity and increase the stability of the structure. During my PhD. work I explored the synthesis and the analysis of some conformationally constrained peptidomimetics which potentially could be employed in different scientific fields.
|Titolo:||Exploring Design, Synthesis and Analysis of New Conformational Restricted Peptidomimetic Compounds|
|Data di pubblicazione:||2009|
|Settore Scientifico Disciplinare:||Settore CHIM/06 - Chimica Organica|
|Citazione:||Exploring Design, Synthesis and Analysis of New Conformational Restricted Peptidomimetic Compounds ; tutor: Giordano Lesma. - Milano : Università degli studi di Milano. DIPARTIMENTO DI CHIMICA ORGANICA E INDUSTRIALE, 2009. ((22. ciclo, Anno Accademico 2008/2009.|
|Appare nelle tipologie:||13 - Tesi di dottorato discussa entro ottobre 2010|