The model of cancer stem cells in tumor development states that tumors contain a subset of cells that both self renew and give rise to differentiated progeny. Like normal adult tissue stem cells, cancer stem cells are a minority of the whole tumor and are the only cells that are able to maintain tumor growth indefinitely. In the present review is critically discussed the actually existence of a cancer stem cell subpopulation in melanoma. The self-renewal signaling pathways as well as specific markers like as CD133, ABCB5 and ABCG2 recently identified in putative melanoma cancer stem cells are also discussed.
|Titolo:||Cancer Stem cells : lessons from melanoma|
LA PORTA, CATERINA (Primo)
|Parole Chiave:||ABCB5; ABCG2; Cancer stem cells; CD133; Self-renewal|
|Settore Scientifico Disciplinare:||Settore MED/04 - Patologia Generale|
|Data di pubblicazione:||2009|
|Digital Object Identifier (DOI):||10.1007/s12015-008-9048-7|
|Appare nelle tipologie:||01 - Articolo su periodico|