To evaluate the association between alcohol consumption and endometrial cancer risk, we analyzed data from a hospital-based case-control study, conducted in Italy between 1992 and 2006, on 454 endometrial cancer cases and 908 controls, and performed a meta-analysis updated to October 2009. Compared to never alcohol drinkers, the odds ratio was 1.03 (95% confidence interval, CI, 0.76-1.41) for ≥ 7, 1.27 (95% CI 0.86-1.87) for 8-14, and 1.19 (95% CI 0.80-1.77) for ≥ 15 drinks/week, with no trend in risk. No association emerged for wine, beer, and spirit consumption analyzed separately. The meta-analysis included 20 case-control and seven cohort studies, for a total of 13,120 cases. Compared to non/low drinkers, the pooled relative risks for drinkers were 0.90 (95% CI 0.80-1.01) for case-control studies, 1.01 (95% CI 0.90-1.14) for cohort studies, and 0.95 (95% CI 0.88-1.03) overall, with no heterogeneity between study design (p = 0.156). The overall estimate for heavy versus non/low drinkers was 1.12 (95% CI 0.87-1.45). The results were consistent according to selected study characteristics, including geographic area, definition of alcohol drinkers, and type of controls in case-control studies. Our findings provide evidence that alcohol drinking is not associated with endometrial cancer risk, although a weak positive association for very high drinkers cannot be excluded.
Alcohol and endometrial cancer risk : a case-control study and a meta-analysis / F. Turati, S. Gallus, A. Tavani, I. Tramacere, J. Polesel, R. Talamini, M. Montella, L. Scotti, S. Franceschi, C. La Vecchia. - In: CANCER CAUSES & CONTROL. - ISSN 0957-5243. - 21:8(2010), pp. 1285-1296.
|Titolo:||Alcohol and endometrial cancer risk : a case-control study and a meta-analysis|
TURATI, FEDERICA (Primo)
|Parole Chiave:||Alcohol; Case-control study; Endometrial cancer risk; Meta-analysis|
|Settore Scientifico Disciplinare:||Settore MED/01 - Statistica Medica|
|Data di pubblicazione:||2010|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1007/s10552-010-9556-z|
|Appare nelle tipologie:||01 - Articolo su periodico|