In this study we analyzed the effect on behavior of a chronic exposure to brain-derived neurotrophic factor (BDNF), by analysing a mouse line overexpressing BDNF under the αCaMKII promoter, which drives the transgene expression exclusively to principal neurons of the forebrain. BDNF transgenic mice and their WT littermates were examined with a battery of behavioral tests, in order to evaluate motor coordination, learning, short and long-term memory formation. Our results demonstrate that chronic BDNF overexpression in the central nervous system (CNS) causes learning deficits and short-term memory impairments, both in spatial and instrumental learning tasks. This observation suggests that a widespread increase in BDNF in forebrain networks may result in adverse effects on learning and memory formation.
|Titolo:||Brain-derived neurotrophic factor (BDNF) overexpression in the forebrain results in learning and memory impairments|
|Parole Chiave:||BDNF; Passive avoidance; Short-term memory; Spatial learning|
|Settore Scientifico Disciplinare:||Settore BIO/10 - Biochimica|
|Data di pubblicazione:||mar-2009|
|Digital Object Identifier (DOI):||10.1016/j.nbd.2008.11.004|
|Appare nelle tipologie:||01 - Articolo su periodico|