As the life expectancy of β-thalassemia patients has markedly improved over the last decade, several new complications are being recognized. The presence of a high incidence of thromboembolic events, mainly in thalassemia intermedia patients, has led to the identification of a hypercoagulable state in thalassemia. In this review, the molecular and cellular mechanisms leading to hypercoagulability in thalassemia are highlighted, and the current clinical experience is summarized. Recommendations for thrombosis prophylaxis are also discussed.
Redefining thalassemia as a hypercoagulable state / M.D. Cappellini, I. Motta, K.M. Musallam, A.T. Taher. - In: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. - ISSN 0077-8923. - 1202:(2010 Aug), pp. 231-236. ((Intervento presentato al 9. convegno Cooleys Anemia Symposium tenutosi a New York nel 2009 [10.1111/j.1749-6632.2010.05548.x].
Redefining thalassemia as a hypercoagulable state
M.D. CappelliniPrimo
;I. MottaSecondo
;
2010
Abstract
As the life expectancy of β-thalassemia patients has markedly improved over the last decade, several new complications are being recognized. The presence of a high incidence of thromboembolic events, mainly in thalassemia intermedia patients, has led to the identification of a hypercoagulable state in thalassemia. In this review, the molecular and cellular mechanisms leading to hypercoagulability in thalassemia are highlighted, and the current clinical experience is summarized. Recommendations for thrombosis prophylaxis are also discussed.
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