A few 2,6-disubstituted benzothiazoles have been prepared as reference compounds or starting material for the preparation of derivatives containing positron emitting fluorine in the aromatic ring. Their affinity for Photinus pyralis luciferase has been evaluated and values of IC50 (8.8-45.2 μM) suggest that they are competitive inhibitors of the enzyme.

2,6-Disubstituted benzothiazoles, analogues of the aromatic core of D-luciferin : synthesis and evaluation of the affinity for Photinus pyralis luciferase / G. Meroni, P. Ciana, M.C. Meda, A.C. Maggi, E. Santaniello. - In: ARKIVOC. - ISSN 1551-7004. - 2009:11(2009), pp. 22-30.

2,6-Disubstituted benzothiazoles, analogues of the aromatic core of D-luciferin : synthesis and evaluation of the affinity for Photinus pyralis luciferase

G. Meroni
Primo
;
P. Ciana
Secondo
;
M.C. Meda;A.C. Maggi
Penultimo
;
E. Santaniello
Ultimo
2009

Abstract

A few 2,6-disubstituted benzothiazoles have been prepared as reference compounds or starting material for the preparation of derivatives containing positron emitting fluorine in the aromatic ring. Their affinity for Photinus pyralis luciferase has been evaluated and values of IC50 (8.8-45.2 μM) suggest that they are competitive inhibitors of the enzyme.
Luciferase; D-luciferin; 2,6-disubstituted benzothiazoles
Settore BIO/10 - Biochimica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/147471
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