Purpose:To study whether ipsilateral breast tumour recurrence (IBTR) dynamics are modified by post-operative radiotherapy (RT). Methods and materials:The hazard rate for IBTR was analysed in a database from patients undergoing breast conserving surgery with or without post-operative radiotherapy within randomised clinical trials from the Milan Cancer Institute. Results:The hazard rate for IBTR presents a bimodal pattern. Post-operative radiotherapy, in addition to reducing IBTR incidence from 24.5 to 5.8 at 10 years, causes more than a one year delay in its clinical manifestation. Distant metastasis dynamics are not modified by radiotherapy administration. Conclusions:In the light of a biology-based model of breast cancer metastasis development, IBTR peak delay most likely originates in a more prolonged dormancy time that, in turn, is related to local microenvironment conditions. Present clinical findings suggest that, besides a direct killing effect on residual tumour cells, microenvironmental modifications may play a major role in RT effectiveness.

Ipsilateral breast tumour recurrence (IBTR) dynamics in breast conserving treatments with or without radiotherapy / R. Demicheli, I. Ardoino, P. Boracchi, L. Lozza, E. Biganzoli. - In: INTERNATIONAL JOURNAL OF RADIATION BIOLOGY. - ISSN 0955-3002. - 86:7(2010), pp. 542-547.

Ipsilateral breast tumour recurrence (IBTR) dynamics in breast conserving treatments with or without radiotherapy

I. Ardoino;P. Boracchi;E. Biganzoli
2010

Abstract

Purpose:To study whether ipsilateral breast tumour recurrence (IBTR) dynamics are modified by post-operative radiotherapy (RT). Methods and materials:The hazard rate for IBTR was analysed in a database from patients undergoing breast conserving surgery with or without post-operative radiotherapy within randomised clinical trials from the Milan Cancer Institute. Results:The hazard rate for IBTR presents a bimodal pattern. Post-operative radiotherapy, in addition to reducing IBTR incidence from 24.5 to 5.8 at 10 years, causes more than a one year delay in its clinical manifestation. Distant metastasis dynamics are not modified by radiotherapy administration. Conclusions:In the light of a biology-based model of breast cancer metastasis development, IBTR peak delay most likely originates in a more prolonged dormancy time that, in turn, is related to local microenvironment conditions. Present clinical findings suggest that, besides a direct killing effect on residual tumour cells, microenvironmental modifications may play a major role in RT effectiveness.
breast cancer; breast conserving surgery; IBTR dynamics; post-operative RT; tumour dormancy
Settore MED/01 - Statistica Medica
Settore MED/06 - Oncologia Medica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/147367
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