To design efficient targeting strategies in magnetic resonance (MR) molecular imaging applications, the formation of supramolecular adducts between (strept)avidin ((S)Av) and tribiotinylated Gd-DOTA-monoamide complexes (DOTA=1,4,7,10-tetraazacyclododecane- N,N’,N’’,N’’’-tetraacetic acid) was explored
Target Visualization by MRI using the Avidin/Biotin amplification route. Synthesis and testing of a Biotin-GdDOTA monoamide trimer / L. Tei, A. Barge, S. Geninatti Crich, R. Pagliarin, V. Negri, D. Ramella, G. Cravotto, S. Aime. - In: CHEMISTRY-A EUROPEAN JOURNAL. - ISSN 0947-6539. - 16:27(2010), pp. 8080-8087. [10.1002/chem.201000508]
Target Visualization by MRI using the Avidin/Biotin amplification route. Synthesis and testing of a Biotin-GdDOTA monoamide trimer
R. Pagliarin;D. Ramella;
2010
Abstract
To design efficient targeting strategies in magnetic resonance (MR) molecular imaging applications, the formation of supramolecular adducts between (strept)avidin ((S)Av) and tribiotinylated Gd-DOTA-monoamide complexes (DOTA=1,4,7,10-tetraazacyclododecane- N,N’,N’’,N’’’-tetraacetic acid) was explored
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