Gangliosides, characteristic complex lipids present in the external layer of plasma membranes, deeply influence the organization of the membrane as a whole and the function of specific membrane associated proteins due to lipid-lipid and lipid-protein lateral interaction. Here we discuss the basis for the membrane-organizing potential of gangliosides, examples of ganglioside-regulated membrane protein complexes and the mechanisms for the regulation of ganglioside membrane composition.
Gangliosides as Regulators of cell Membrane Organization and Functions / S. Sonnino, A.E.G. Prinetti. - 688:(2010), pp. 165-184. [10.1007/978-1-4419-6741-1_12]
Gangliosides as Regulators of cell Membrane Organization and Functions
S. SonninoPrimo
;A.E.G. PrinettiUltimo
2010
Abstract
Gangliosides, characteristic complex lipids present in the external layer of plasma membranes, deeply influence the organization of the membrane as a whole and the function of specific membrane associated proteins due to lipid-lipid and lipid-protein lateral interaction. Here we discuss the basis for the membrane-organizing potential of gangliosides, examples of ganglioside-regulated membrane protein complexes and the mechanisms for the regulation of ganglioside membrane composition.
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