Chemokines induce cell migration through the activation of a distinct family of structurally related heterotrimeric G protein-coupled receptors (GPCR). Over the last few years, several receptors in this family that recognize chemokines but do not induce cell migration have been identified. These "atypical" chemokine receptors are unable to activate transduction events that lead directly to cell migration, but appear nonetheless to play a nonredundant role in the control of leukocyte recruitment at inflammatory sites and in tumors by shaping the chemoattractant gradient, either by removing, transporting, or concentrating their cognate ligands.
Chemokine decoy receptors: structure-function and biological properties / R. Bonecchi, B. Savino, E.M. Borroni, A. Mantovani, M. Locati. - In: CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY. - ISSN 0070-217X. - 870:1(2010), pp. 15-36. [10.1007/82_2010_19]
Chemokine decoy receptors: structure-function and biological properties
B. Savino;E.M. Borroni;M. LocatiUltimo
2010
Abstract
Chemokines induce cell migration through the activation of a distinct family of structurally related heterotrimeric G protein-coupled receptors (GPCR). Over the last few years, several receptors in this family that recognize chemokines but do not induce cell migration have been identified. These "atypical" chemokine receptors are unable to activate transduction events that lead directly to cell migration, but appear nonetheless to play a nonredundant role in the control of leukocyte recruitment at inflammatory sites and in tumors by shaping the chemoattractant gradient, either by removing, transporting, or concentrating their cognate ligands.
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