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EnglishSpinal and bulbar muscular atrophy (SBMA or Kennedy's disease) is a fatal neurodegenerative disease characterized by the selective loss of motor neurons in the bulbar region of the brain and in the anterior horns of the spinal cord. The disease has been associated to an expansion of a CAG triplet repeat present in the first coding exon of the androgen receptor (AR) gene. SBMA was the first identified member of a large class of neurodegenerative diseases now known as CAG-related diseases, which includes Huntington's disease (HD), several types of spinocerebellar ataxia (SCAs), and dentatorubral and pallidoluysian atrophy (DRPLA). The expanded CAG tract is translated to an aberrantly long polyglutamine tract (ARpolyQ) in the Nterminal region of the AR protein. The elongated polyQ tract seems to confer a neurotoxic gain-of-function to the mutant AR, possibly via the generation of aberrant conformations (misfolding). Protein misfolding is thought to be a trigger of neurotoxicity, since it perturbs a wide variety of motor neuronal functions. The first event is the accumulation of the ARpolyQ into ubiquitinated aggregates in a ligand (testosterone) dependent manner. The mutant ARpolyQ also impairs proteasome functions. The autophagic pathway may be activated to compensate these aberrant events by clearing the mutant ARpolyQ from motor neuronal cells. This review illustrates the mechanisms at the basis of ARpolyQ degradation via the proteasomal and autophagic system
Proteasomal and autophagic degradative activities in spinal and bulbar muscular atrophy / P. Rusmini, E. Bolzoni, V. Crippa, E. Onesto, D. Sau, M. Galbiati, M. Piccolella, A. Poletti. - In: NEUROBIOLOGY OF DISEASE. - ISSN 0969-9961. - 40:2(2010), pp. 361-369.
| Titolo: | Proteasomal and autophagic degradative activities in spinal and bulbar muscular atrophy | |
| Autori: | ||
| Parole Chiave: | motorneuron ; androgen receptor ; SBMA ; kennedy's disease ; proteasome ; autophagy | |
| Settore Scientifico Disciplinare: | Settore BIO/13 - Biologia Applicata Settore BIO/09 - Fisiologia | |
| Data di pubblicazione: | 2010 | |
| Rivista: | ||
| Tipologia: | Article (author) | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.nbd.2010.06.016 | |
| Appare nelle tipologie: | 01 - Articolo su periodico |
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|---|---|---|---|---|
| Rusmini 2010 Neurobiol Dis.pdf | Publisher's version/PDF | Administrator Richiedi una copia |
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