AIRmax and AIRmin mouse lines show a differential lung inflammatory response and differential lung tumor susceptibility after urethane treatment. The transcript profile of 24,000 known genes was analyzed in normal lung tissue of untreated and urethane-treated AIRmax and AIRmin mice. In lungs of untreated mice, inflammation-associated genes involved in pathways such as “leukocyte transendothelial migration”, “cell adhesion” and “tight junctions” were differentially expressed. Moreover, gene expression levels differed significantly in urethane-treated mice; in AIRmin mice, modulation of expression of genes involved in pathways associated with inflammatory response paralleled the previously observed persistent infiltration of inflammatory cells in the lung of these mice.
|Titolo:||Transcriptome of normal lung distinguishes mouse lines with different susceptibility to inflammation and to lung tumorigenesis|
|Parole Chiave:||microarray ; mRNA profile ; inflammatory response ; animal models|
|Settore Scientifico Disciplinare:||Settore MED/01 - Statistica Medica|
|Data di pubblicazione:||28-ago-2010|
|Digital Object Identifier (DOI):||10.1016/j.canlet.2010.01.038|
|Appare nelle tipologie:||01 - Articolo su periodico|