The invention relates to a process for the distereoisomeri resolution of 5-Methyltetrahydrofolic acid; it discloses also a cristalline amine salt of 5-Methyltetrahydrofolic acid and is furthe directed to a process for the transformation of the single diastereoisomers of the 5-Methyltetrahydrofolic amine salts obtained by the process of the invnetion into the corresponding free acid or into an alkaline earth matal salt. The inventio provides a simple, economically advantageous and efficient process and allows to obtain stable and pure (6R) and (6S)- diastereoisomers of 5-Methyltetrahydrofolic acid in good yield and diastereoisomeric putity.
Process for the diastereoisomeric resolution of 5-Methyltetrahydrofolic acid / E. Valoti, D. Bianchi, M. Valetti.
Process for the diastereoisomeric resolution of 5-Methyltetrahydrofolic acid
E. ValotiPrimo
;
2009
Abstract
The invention relates to a process for the distereoisomeri resolution of 5-Methyltetrahydrofolic acid; it discloses also a cristalline amine salt of 5-Methyltetrahydrofolic acid and is furthe directed to a process for the transformation of the single diastereoisomers of the 5-Methyltetrahydrofolic amine salts obtained by the process of the invnetion into the corresponding free acid or into an alkaline earth matal salt. The inventio provides a simple, economically advantageous and efficient process and allows to obtain stable and pure (6R) and (6S)- diastereoisomers of 5-Methyltetrahydrofolic acid in good yield and diastereoisomeric putity.
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