von Willebrand disease is the most common inherited bleeding disorder in humans. VWD can be classified into three major types, designated Types 1, 2 and 3; Type 2 can be further separated into subtypes 2A, 2B, 2M and 2N. The diagnosis of VWD requires a personal and family history of bleeding and confirmation by laboratory analysis. Although Types 2 and 3 are relatively straightforward to diagnose, there may be a risk of overdiagnosis of Type 1 because of an overlap within the normal range. We also report on the clinical profile and diagnosis of VWD in a South American cohort of patients and on the in vitro characteristics of some factor concentrates available for treatment of VWD.
von Willebrand disease : laboratory aspects of diagnosis and treatment / E.J. Favaloro, D. Lillicrap, M.A. Lazzari, M.N. Cattaneo, C. Mazurier, A. Woods, S. Meschengieser, A. Blanco, A.C. Kempfer, A. Hubbard, A. Chang. - In: HAEMOPHILIA. - ISSN 1351-8216. - 10:Suppl. 4(2004 Oct), pp. 164-168. [10.1111/j.1365-2516.2004.00979.x]
von Willebrand disease : laboratory aspects of diagnosis and treatment
M.N. Cattaneo;
2004
Abstract
von Willebrand disease is the most common inherited bleeding disorder in humans. VWD can be classified into three major types, designated Types 1, 2 and 3; Type 2 can be further separated into subtypes 2A, 2B, 2M and 2N. The diagnosis of VWD requires a personal and family history of bleeding and confirmation by laboratory analysis. Although Types 2 and 3 are relatively straightforward to diagnose, there may be a risk of overdiagnosis of Type 1 because of an overlap within the normal range. We also report on the clinical profile and diagnosis of VWD in a South American cohort of patients and on the in vitro characteristics of some factor concentrates available for treatment of VWD.
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