The diastereoselective cycloadditions of enantiopure nitrilimines 4 with ethyl acrylate were exploited in dry toluene and in aqueous sodium hydrogencarbonate as reaction media. Shorter reaction times and improved diastereoisomeric ratios of the resulting 5-ethoxycarbonyl-4,5-dihydropyrazoles 5 and 6 were observed in aqueous media.
The first case of diastereoselective cycloadditions of enantiopure nitrilimines in aqueous media / G. Molteni. - In: TETRAHEDRON-ASYMMETRY. - ISSN 0957-4166. - 15:7(2004), pp. 1077-1079. [10.1016/j.tetasy.2004.02.006]
The first case of diastereoselective cycloadditions of enantiopure nitrilimines in aqueous media
G. Molteni
2004
Abstract
The diastereoselective cycloadditions of enantiopure nitrilimines 4 with ethyl acrylate were exploited in dry toluene and in aqueous sodium hydrogencarbonate as reaction media. Shorter reaction times and improved diastereoisomeric ratios of the resulting 5-ethoxycarbonyl-4,5-dihydropyrazoles 5 and 6 were observed in aqueous media.
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