The asymmetric hydroformylation of variously N-substituted 4-vinyl -lactams catalyzed by rhodium aminophosphonite-phosphinite and rhodium aminophosphine-phosphite complexes was studied. The products are valuable intermediates in the preparation of 1-methyl carbapenem antibiotics; the stereoselectivity to the desired -isomer is related to the presence of a substituent at the N atom of the -lactam ring. The regioselectivity (branched/linear) but not the stereoselectivity () was found to be dependent on the substrate to catalyst ratio.
|Titolo:||Stereoselective synthesis of 1-methylcarbapenem precursors : studies on the diastereoselective hydroformylation of 4-vinyl b-lactam with aminophosphonite–phosphinite and aminophosphine–phosphite rhodium(I) complexes|
CESAROTTI, EDOARDO (Primo)
RIMOLDI, ISABELLA (Ultimo)
|Settore Scientifico Disciplinare:||Settore CHIM/03 - Chimica Generale e Inorganica|
|Data di pubblicazione:||25-ott-2004|
|Digital Object Identifier (DOI):||10.1016/j.tetasy.2004.10.021|
|Appare nelle tipologie:||01 - Articolo su periodico|