Statin monotherapy is generally well tolerated, with a low frequency of adverse events. The most important adverse effects associated with statins are myopathy and an asymptomatic increase in hepatic transaminases, both of which occur infrequently. Because statins are prescribed on a long-term basis, however, possible interactions with other drugs deserve particular attention, as many patients will typically receive pharmacological therapy for concomitant conditions during the course of statin treatment. This review summarizes the pharmacokinetic properties of statins and emphasizes their clinically relevant drug interactions.
Safety of statins: focus on clinical pharmacokinetics and drug interactions / S. Bellosta, R. Paoletti, A. Corsini. - In: CIRCULATION. - ISSN 0009-7322. - 109:23 (Suppl. 1)(2004 Jun 15), pp. III-50-III-57.
Safety of statins: focus on clinical pharmacokinetics and drug interactions
S. BellostaPrimo
;R. PaolettiSecondo
;A. CorsiniUltimo
2004
Abstract
Statin monotherapy is generally well tolerated, with a low frequency of adverse events. The most important adverse effects associated with statins are myopathy and an asymptomatic increase in hepatic transaminases, both of which occur infrequently. Because statins are prescribed on a long-term basis, however, possible interactions with other drugs deserve particular attention, as many patients will typically receive pharmacological therapy for concomitant conditions during the course of statin treatment. This review summarizes the pharmacokinetic properties of statins and emphasizes their clinically relevant drug interactions.File | Dimensione | Formato | |
---|---|---|---|
2004 Circulation Safety of statins.pdf
accesso aperto
Tipologia:
Publisher's version/PDF
Dimensione
331.52 kB
Formato
Adobe PDF
|
331.52 kB | Adobe PDF | Visualizza/Apri |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.