The thesis describes the discovery of mono- and poly-valent glycomimetic compounds which inhibit the dendritic cell lectin DC-SIGN. Some of these compounds also showed a high activity as inhibitors of DC-SIGN mediated HIV infection on model cells.
Synthesis of Inhibitors of DC-SIGN Mediated Infections / S. Sattin ; tutor: Anna Bernardi ; coordinatore: Franco Cozzi. DIPARTIMENTO DI CHIMICA ORGANICA E INDUSTRIALE, 2009 Dec. 22. ciclo, Anno Accademico 2008/2009.
Synthesis of Inhibitors of DC-SIGN Mediated Infections
S. Sattin
2009
Abstract
The thesis describes the discovery of mono- and poly-valent glycomimetic compounds which inhibit the dendritic cell lectin DC-SIGN. Some of these compounds also showed a high activity as inhibitors of DC-SIGN mediated HIV infection on model cells.
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