A novel, straightforward synthesis of enantiomerically pure 2,6-disubstituted morpholines has been developed. The ring opening of epoxides with TsNHBoc under solid-liquid phase transfer catalysis conditions occurred with N→O migration of the Boc group affording an intermediate carbonate that has been easily transformed to morpholines
Concise Synthesis of C-2-Symmetrical 2,6-Disubstituted Morpholines by N → O Boc Migration under SL-PTC conditions / D. Albanese, D. Landini, M. Penso, A. Tagliabue, E. Carlini. - In: ORGANIC PROCESS RESEARCH & DEVELOPMENT. - ISSN 1083-6160. - 14:3(2010), pp. 705-711.
Titolo: | Concise Synthesis of C-2-Symmetrical 2,6-Disubstituted Morpholines by N → O Boc Migration under SL-PTC conditions |
Autori: | ALBANESE, DOMENICO (Primo) LANDINI, DARIO (Secondo) TAGLIABUE, AARON LUCA (Penultimo) |
Settore Scientifico Disciplinare: | Settore CHIM/04 - Chimica Industriale |
Data di pubblicazione: | 2010 |
Rivista: | |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1021/op1000435 |
Appare nelle tipologie: | 01 - Articolo su periodico |
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