AQPs are water channel proteins. In particular, AQP1 was demonstrated to be involved in cell migration. According to the model proposed by Verkman and collaborators, AQP drives water influx, facilitating lamellipodia extension and cell migration. Investigating the possible connection between AQP1 and cytoskeleton, our group showed that such a water channel through Lin7/beta catenin affects the organization of the cytoskeleton and proposed a model. All together, these data appear particularly intriguing since the use of AQP1 as target might be useful to modulate angiogenesis/vasculogenic mimicry.
|Titolo:||AQP1 is not only a water channel: it contributes to cell migration through Lin7/beta-catenin|
LA PORTA, CATERINA (Primo)
|Parole Chiave:||AQP; Beta-catenin; Cytoskeleton; Lin7; Molecular adhesion; Motility|
|Settore Scientifico Disciplinare:||Settore MED/04 - Patologia Generale|
|Data di pubblicazione:||2010|
|Digital Object Identifier (DOI):||10.4161/cam.4.2.10949|
|Appare nelle tipologie:||01 - Articolo su periodico|