Water-soluble biocompatible rhamnose-coated Fe3O4 nanoparticles of 4.0 nm are obtained by covalent anchorage of rhamnose on the nanoparticles surface via a phosphate linker. These nanoparticles present superparamagnetic behavior and nuclear relaxivities in the same order of magnitude as Endorem that make them potential magnetic resonance imaging (MRI) contrast agents of a second generation, where the saccharides represent also specific ligands able to target lectins on skin cells.
Water-Soluble Rhamnose-Coated Fe3O4 Nanoparticles / L. Lartigue, K. Oumzil, Y. Guari, J. Larionova, C. GueLrin, J.-L. Montero, V. Barragan-Montero, C. Sangregorio, A. Caneschi, C. Innocenti, K. Thangavel, P. Arosio, A. Lascialfari. - In: ORGANIC LETTERS. - ISSN 1523-7060. - 11:14(2009), pp. 2992-2995.
Water-Soluble Rhamnose-Coated Fe3O4 Nanoparticles
K. Thangavel;P. ArosioPenultimo
;A. LascialfariUltimo
2009
Abstract
Water-soluble biocompatible rhamnose-coated Fe3O4 nanoparticles of 4.0 nm are obtained by covalent anchorage of rhamnose on the nanoparticles surface via a phosphate linker. These nanoparticles present superparamagnetic behavior and nuclear relaxivities in the same order of magnitude as Endorem that make them potential magnetic resonance imaging (MRI) contrast agents of a second generation, where the saccharides represent also specific ligands able to target lectins on skin cells.
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