A novel poly(sodium methacrylate, methylmethacrylate) hydrophilic pressure sensitive adhesive (PSA) containing a large amount of water was designed. The effects of PEG400, glycerin, sorbitol, and/or NaCl on the in vitro and in vivo adhesive properties were investigated by means of a 24 full factorial design. The optimized formulation, containing all independent variables at the highest value, was loaded with lidocaine hydrochloride (LH). This formulation permitted to obtain a 4-fold higher LH flux through human skin with respect to the marketed products.
A novel polymethylmethacrylate hydrophilic adhesive matrix intended for transdermal patch formulations / F. Cilurzo, P. Minghetti, C.G.M. Gennari, A. Casiraghi, L. Montanari. - In: DRUG DELIVERY. - ISSN 1071-7544. - 17:3(2010 Apr), pp. 171-177.
|Titolo:||A novel polymethylmethacrylate hydrophilic adhesive matrix intended for transdermal patch formulations|
CILURZO, FRANCESCO (Primo)
MINGHETTI, PAOLA (Secondo)
CASIRAGHI, ANTONELLA (Penultimo)
MONTANARI, LUISA (Ultimo)
|Parole Chiave:||Full factorial design; Lidocaine; Methylmethacrylate) (PMM); Poly(sodium methacrylate; Pressure sensitive adhesive (PSA); Texture analysis|
|Settore Scientifico Disciplinare:||Settore CHIM/09 - Farmaceutico Tecnologico Applicativo|
|Data di pubblicazione:||apr-2010|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3109/10717541003667772|
|Appare nelle tipologie:||01 - Articolo su periodico|