A novel poly(sodium methacrylate, methylmethacrylate) hydrophilic pressure sensitive adhesive (PSA) containing a large amount of water was designed. The effects of PEG400, glycerin, sorbitol, and/or NaCl on the in vitro and in vivo adhesive properties were investigated by means of a 24 full factorial design. The optimized formulation, containing all independent variables at the highest value, was loaded with lidocaine hydrochloride (LH). This formulation permitted to obtain a 4-fold higher LH flux through human skin with respect to the marketed products.

A novel polymethylmethacrylate hydrophilic adhesive matrix intended for transdermal patch formulations / F. Cilurzo, P. Minghetti, C.G.M. Gennari, A. Casiraghi, L. Montanari. - In: DRUG DELIVERY. - ISSN 1071-7544. - 17:3(2010 Apr), pp. 171-177. [10.3109/10717541003667772]

A novel polymethylmethacrylate hydrophilic adhesive matrix intended for transdermal patch formulations

F. Cilurzo
Primo
;
P. Minghetti
Secondo
;
C.G.M. Gennari;A. Casiraghi
Penultimo
;
L. Montanari
Ultimo
2010

Abstract

A novel poly(sodium methacrylate, methylmethacrylate) hydrophilic pressure sensitive adhesive (PSA) containing a large amount of water was designed. The effects of PEG400, glycerin, sorbitol, and/or NaCl on the in vitro and in vivo adhesive properties were investigated by means of a 24 full factorial design. The optimized formulation, containing all independent variables at the highest value, was loaded with lidocaine hydrochloride (LH). This formulation permitted to obtain a 4-fold higher LH flux through human skin with respect to the marketed products.
Full factorial design; Lidocaine; Methylmethacrylate) (PMM); Poly(sodium methacrylate; Pressure sensitive adhesive (PSA); Texture analysis
Settore CHIM/09 - Farmaceutico Tecnologico Applicativo
apr-2010
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/141498
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