A novel poly(sodium methacrylate, methylmethacrylate) hydrophilic pressure sensitive adhesive (PSA) containing a large amount of water was designed. The effects of PEG400, glycerin, sorbitol, and/or NaCl on the in vitro and in vivo adhesive properties were investigated by means of a 24 full factorial design. The optimized formulation, containing all independent variables at the highest value, was loaded with lidocaine hydrochloride (LH). This formulation permitted to obtain a 4-fold higher LH flux through human skin with respect to the marketed products.
A novel polymethylmethacrylate hydrophilic adhesive matrix intended for transdermal patch formulations / F. Cilurzo, P. Minghetti, C.G.M. Gennari, A. Casiraghi, L. Montanari. - In: DRUG DELIVERY. - ISSN 1071-7544. - 17:3(2010 Apr), pp. 171-177. [10.3109/10717541003667772]
A novel polymethylmethacrylate hydrophilic adhesive matrix intended for transdermal patch formulations
F. CilurzoPrimo
;P. MinghettiSecondo
;C.G.M. Gennari;A. CasiraghiPenultimo
;L. MontanariUltimo
2010
Abstract
A novel poly(sodium methacrylate, methylmethacrylate) hydrophilic pressure sensitive adhesive (PSA) containing a large amount of water was designed. The effects of PEG400, glycerin, sorbitol, and/or NaCl on the in vitro and in vivo adhesive properties were investigated by means of a 24 full factorial design. The optimized formulation, containing all independent variables at the highest value, was loaded with lidocaine hydrochloride (LH). This formulation permitted to obtain a 4-fold higher LH flux through human skin with respect to the marketed products.Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.