Tramadol is a synthetic opioid agonist used extensively in human and, to a lesser extent, veterinary medicine throughout the world. The clinical efficacy and pharmacokinetic profile of intravenous (IV) and extradural (ED) tramadol (2 mg/kg) and its o-desmethyl metabolite were studied in dogs undergoing tibial plateau levelling osteotomy (TPLO). Intra-operative cardiorespiratory variables were monitored and post-operative pain was assessed using the short form of the Glasgow Composite Pain Scale. A rapid (<5 min) and effective production of o-desmethyl tramadol was recorded. The pharmacokinetic profile was similar for tramadol and its metabolite irrespective of the route of administration. ED tramadol provided sufficient intra- and post-operative analgesia without significant clinical side-effects, but the post-operative analgesia was comparable to that following IV administration and the ED route could therefore not be considered a practical alternative to the IV route.
Pharmacokinetics and efficacy of intravenous and extradural tramadol in dogs / E. Vettorato, A. Zonca, M. Isola, R.E. Villa, M. Gallo, G. Ravasio, M. Beccaglia, C. Montesissa, P. Cagnardi. - In: THE VETERINARY JOURNAL. - ISSN 1090-0233. - 183:3(2010 Mar), pp. 310-315.
|Titolo:||Pharmacokinetics and efficacy of intravenous and extradural tramadol in dogs|
ZONCA, ANNALISA (Secondo)
CAGNARDI, PETRA PICO' (Ultimo)
|Parole Chiave:||Dog; Efficacy; Extradural; Pharmacokinetics; Tramadol|
|Settore Scientifico Disciplinare:||Settore VET/07 - Farmacologia e Tossicologia Veterinaria|
Settore VET/09 - Clinica Chirurgica Veterinaria
Settore VET/10 - Clinica Ostetrica e Ginecologia Veterinaria
|Data di pubblicazione:||mar-2010|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.tvjl.2008.11.002|
|Appare nelle tipologie:||01 - Articolo su periodico|