Objective: To evaluate whether the effect of chronic or acute cigarette smoking on endothelial function is related to the cigarette content of tar, nicotine or carbon-monoxide (CO) reported on the pack. Methods: Cigarettes were defined as “light” or “regular” on the basis of the concomitant presence of tar, nicotine and CO above or below 7, 0.7 and 7 mg, respectively. Brachial artery flow mediated dilation (FMD) of 45 consumers of light cigarettes was compared to that of 45 consumers of regular cigarettes, matched for age, gender and pack-years. Forty-five never smokers, matched for age and gender, were included as negative controls. The acute effect of a light or a regular cigarette on FMD was assessed in 81 smokers, who were asked to smoke a single light (n=52) or regular (n=29) cigarette. In these subjects, FMD was measured before and 10 minutes after the single cigarette smoking. Results: FMD of light (2.78±3.13%) and regular (4.03±2.93%) cigarettes consumers were lower than in never smokers (6.26%±3.21; both p<0.002). In contrast, no difference was observed when light and regular cigarettes consumers were compared (p=0.173). A single cigarette smoking caused an FMD reduction of about 39% (p<0.0001), but also in this case, no difference was detectable comparing light or regular cigarettes (-36.9% vs. -47.0%, respectively; p=0.168). Conclusions: Consumption of light cigarettes is not associated with a lower detrimental effect on endothelial dysfunction. Light cigarettes consumption should not be considered a valid alternative to smoking cessation. Funding: Research was supported in part by Philip Morris USA Inc. and Philip Morris International.
Light or regular cigarettes consumption: effect on endothelial function / B. Frigerio, S. Castelnuovo, M. Amato, A. Ravani, E. Tremoli, C. Sirtori, D. Baldassarre. - In: ATHEROSCLEROSIS SUPPLEMENTS. - ISSN 1567-5688. - 10:2(2009), pp. e1046-e1046. ((Intervento presentato al 15. convegno International Symposium on Atherosclerosis tenutosi a Boston nel 2009 [10.1016/S1567-5688(09)71022-0].
Light or regular cigarettes consumption: effect on endothelial function
B. FrigerioPrimo
;S. CastelnuovoSecondo
;E. Tremoli;C. SirtoriPenultimo
;D. BaldassarreUltimo
2009
Abstract
Objective: To evaluate whether the effect of chronic or acute cigarette smoking on endothelial function is related to the cigarette content of tar, nicotine or carbon-monoxide (CO) reported on the pack. Methods: Cigarettes were defined as “light” or “regular” on the basis of the concomitant presence of tar, nicotine and CO above or below 7, 0.7 and 7 mg, respectively. Brachial artery flow mediated dilation (FMD) of 45 consumers of light cigarettes was compared to that of 45 consumers of regular cigarettes, matched for age, gender and pack-years. Forty-five never smokers, matched for age and gender, were included as negative controls. The acute effect of a light or a regular cigarette on FMD was assessed in 81 smokers, who were asked to smoke a single light (n=52) or regular (n=29) cigarette. In these subjects, FMD was measured before and 10 minutes after the single cigarette smoking. Results: FMD of light (2.78±3.13%) and regular (4.03±2.93%) cigarettes consumers were lower than in never smokers (6.26%±3.21; both p<0.002). In contrast, no difference was observed when light and regular cigarettes consumers were compared (p=0.173). A single cigarette smoking caused an FMD reduction of about 39% (p<0.0001), but also in this case, no difference was detectable comparing light or regular cigarettes (-36.9% vs. -47.0%, respectively; p=0.168). Conclusions: Consumption of light cigarettes is not associated with a lower detrimental effect on endothelial dysfunction. Light cigarettes consumption should not be considered a valid alternative to smoking cessation. Funding: Research was supported in part by Philip Morris USA Inc. and Philip Morris International.Pubblicazioni consigliate
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