Preclinical and clinical studies have shown that N-methyl-D-aspartate (NMDA) receptor antagonists can exert antidepressant effects. Thus, a single intravenous injection of ketamine, a non-competitive NMDA receptor antagonists, has been recently demonstrated to produce a rapid and relatively sustained antidepressant effect in patients. Therefore, the role of NMDA receptors and their signalling pathways for pathophysiology and therapy of depression are under intense research
Differential c-Fos induction by different NMDA receptor antagonists with antidepressant efficacy : potential clinical implications / D. INTA, M. TRUSEL, M.A. RIVA, R. SPRENGEL, P. GASS. - In: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. - ISSN 1461-1457. - 12:8(2009 Sep), pp. 1133-1136.
Differential c-Fos induction by different NMDA receptor antagonists with antidepressant efficacy : potential clinical implications
M.A. RIVA;
2009
Abstract
Preclinical and clinical studies have shown that N-methyl-D-aspartate (NMDA) receptor antagonists can exert antidepressant effects. Thus, a single intravenous injection of ketamine, a non-competitive NMDA receptor antagonists, has been recently demonstrated to produce a rapid and relatively sustained antidepressant effect in patients. Therefore, the role of NMDA receptors and their signalling pathways for pathophysiology and therapy of depression are under intense researchPubblicazioni consigliate
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