Modulation of smooth muscle cells to a proliferating and migrating phenotype with downregulated α-actin expression is observed upon vascular lesion formation. The Id proteins (inhibitors of cell differentiation) play a role in the development of this phenotype. In contrast, synthetic peptides based on a conserved 11-residue Id sequence trigger the switch to a contractile phenotype that shows reduced cell growth and migration, increased expression of α-actin and decreased Id protein levels
Synthetic peptides containing a conserved sequence motif of the Id protein family modulate vascular smooth muscle cell phenotype / S. Pellegrino, N. Ferri, N. Colombo, E. Cremona, A. Corsini, R. Fanelli, M.L. Gelmi, C. Cabrele. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - 19:22(2009 Nov 15), pp. 6298-6302.
Synthetic peptides containing a conserved sequence motif of the Id protein family modulate vascular smooth muscle cell phenotype
S. PellegrinoPrimo
;N. FerriSecondo
;A. Corsini;R. Fanelli;M.L. GelmiPenultimo
;
2009
Abstract
Modulation of smooth muscle cells to a proliferating and migrating phenotype with downregulated α-actin expression is observed upon vascular lesion formation. The Id proteins (inhibitors of cell differentiation) play a role in the development of this phenotype. In contrast, synthetic peptides based on a conserved 11-residue Id sequence trigger the switch to a contractile phenotype that shows reduced cell growth and migration, increased expression of α-actin and decreased Id protein levelsPubblicazioni consigliate
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