Modulation of smooth muscle cells to a proliferating and migrating phenotype with downregulated α-actin expression is observed upon vascular lesion formation. The Id proteins (inhibitors of cell differentiation) play a role in the development of this phenotype. In contrast, synthetic peptides based on a conserved 11-residue Id sequence trigger the switch to a contractile phenotype that shows reduced cell growth and migration, increased expression of α-actin and decreased Id protein levels

Synthetic peptides containing a conserved sequence motif of the Id protein family modulate vascular smooth muscle cell phenotype / S. Pellegrino, N. Ferri, N. Colombo, E. Cremona, A. Corsini, R. Fanelli, M.L. Gelmi, C. Cabrele. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - 19:22(2009 Nov 15), pp. 6298-6302.

Synthetic peptides containing a conserved sequence motif of the Id protein family modulate vascular smooth muscle cell phenotype

S. Pellegrino;N. Ferri;A. Corsini;R. Fanelli;M.L. Gelmi;
2009-11-15

Abstract

Modulation of smooth muscle cells to a proliferating and migrating phenotype with downregulated α-actin expression is observed upon vascular lesion formation. The Id proteins (inhibitors of cell differentiation) play a role in the development of this phenotype. In contrast, synthetic peptides based on a conserved 11-residue Id sequence trigger the switch to a contractile phenotype that shows reduced cell growth and migration, increased expression of α-actin and decreased Id protein levels
Id proteins ; Protein domain recognition ; Helix–loop–helix ; Peptide dimerization ; Peptide mimic ; Solid-phase peptide synthesis ; Smooth muscle cell
Settore BIO/14 - Farmacologia
Settore CHIM/06 - Chimica Organica
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/140535
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