Background: Congenital cytomegalovirus infection causes 20-30% of congenital sensorineural hearing loss (SNHL) cases. Early identification of CMV attributable cases and their successful treatment are often hampered by the late appearance of the damage in a high proportion of children both symptomatic and asymptomatic at birth. Objective: To discuss the feasibility of a screening program aimed at finding congenitally infected babies followed by their audiological monitoring. Study design: Opinion - review article. Results and conclusions: Frequency and severity of hearing loss due to congenital CMV suggest it maybe worthwhile setting up neonatal screening campaigns. Structures where SNHL can be diagnosed and treated exist already in many countries as part of universal neonatal audiological screening schemes. A test based on viral DNA extraction from neonatal dried blood spots on Guthrie cards and its amplification by means of a nested PCR (DBS test) seems to offer the best characteristics for use in screening. Clearly it will be necessary to calculate whether the costs of screening, diagnosis and follow-up, and the financial and emotional burden on the families of infected children, are up to the potential gain. (copyright) 2005 Elsevier B.V. All rights reserved.

Neonatal screening for congenital cytomegalovirus infection and hearing loss / M. Barbi, S. Binda, S. Caroppo, V. Primache. - In: JOURNAL OF CLINICAL VIROLOGY. - ISSN 1386-6532. - 35:2(2006), pp. 206-209. ((Intervento presentato al 10. convegno International CMV/Betaherpesvirus Workshop tenutosi a Williamsburg nel 2005.

Neonatal screening for congenital cytomegalovirus infection and hearing loss

M. Barbi
Primo
;
S. Binda
Secondo
;
S. Caroppo
Penultimo
;
V. Primache
Ultimo
2006

Abstract

Background: Congenital cytomegalovirus infection causes 20-30% of congenital sensorineural hearing loss (SNHL) cases. Early identification of CMV attributable cases and their successful treatment are often hampered by the late appearance of the damage in a high proportion of children both symptomatic and asymptomatic at birth. Objective: To discuss the feasibility of a screening program aimed at finding congenitally infected babies followed by their audiological monitoring. Study design: Opinion - review article. Results and conclusions: Frequency and severity of hearing loss due to congenital CMV suggest it maybe worthwhile setting up neonatal screening campaigns. Structures where SNHL can be diagnosed and treated exist already in many countries as part of universal neonatal audiological screening schemes. A test based on viral DNA extraction from neonatal dried blood spots on Guthrie cards and its amplification by means of a nested PCR (DBS test) seems to offer the best characteristics for use in screening. Clearly it will be necessary to calculate whether the costs of screening, diagnosis and follow-up, and the financial and emotional burden on the families of infected children, are up to the potential gain. (copyright) 2005 Elsevier B.V. All rights reserved.
Congenital infection; Cytomegalovirus; Screening; Sensorineural hearing loss
Settore MED/42 - Igiene Generale e Applicata
http://hdl.handle.net/2434/17805
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/140055
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