Objective To assess whether earliness of CHD (< 60 year of age) is a determinant of carotid intima media thicknes (IMT) in the progeny; and whether the parental history of smoking may act as a confounder in the estimation of atherosclerosis heritability by carotid IMT measurements Method 116 offspring of patients with premature CHD (P-CHD) and 42 offspring of patients with not premature CHD (NP-CHD) were assessed clinically and with carotid B-mode ultrasound Results The age of CHD onset was 50±6y in parents with P-CHD and 64±3y in parents with NP-CHD. These groups had similar prevalence of hypertension, NIDDM and dyslipidemia. History of cigarette smoking was positive in 74% of parents with P-CHD and in 45% of parents with NP-CHD (p<0.001).The offspring were basically healthy young subjects (age 33±5.8; females 51%, never smokers 61%, normal weight 74%; normotensive 89%, LDL-C130 66%). As expected, IMT was significantly lower in females and directly related to age. Progeny of P-CHD and NP-CHD had similar BP, BMI, TC, LDL-C, HDL-C and TG but the former were younger (28.5±5.4 vs. 32.6±2.3 y, p <0.0001). After data adjustment for sex, age, and smoking habits, Max IMT in offspring of P-CHD subjects was significantly higher than in offspring of NP-CHD (0.94±0.02 vs. 0.86±0.03, p=0.048). No differences in IMT measures were found when the progeny of CHD patients with or without history of smoking were compared Conclusions parental earliness of CHD is a determinant of carotid Max IMT in the progeny whereas parental history of smoking is not. Funding Centro Cardiologico Monzino. Italian Ministry of Health
Parental earliness of CHD and parental history of smoking as determinants of carotid IMT in the progeny / J.P. Werba, M. Amato, E.C. Oldani, A.L. Ravani, P.G. Massironi, F. Veglia, E. Tremoli, D. Baldassarre. - In: ATHEROSCLEROSIS SUPPLEMENTS. - ISSN 1567-5688. - 7:3(2006), pp. 204-204. ((Intervento presentato al 14. convegno XIV International Atherosclerosis Symposium tenutosi a Roma nel 2006 [10.1016/S1567-5688(06)80794-4].
Parental earliness of CHD and parental history of smoking as determinants of carotid IMT in the progeny
E. TremoliPenultimo
;D. BaldassarreUltimo
2006
Abstract
Objective To assess whether earliness of CHD (< 60 year of age) is a determinant of carotid intima media thicknes (IMT) in the progeny; and whether the parental history of smoking may act as a confounder in the estimation of atherosclerosis heritability by carotid IMT measurements Method 116 offspring of patients with premature CHD (P-CHD) and 42 offspring of patients with not premature CHD (NP-CHD) were assessed clinically and with carotid B-mode ultrasound Results The age of CHD onset was 50±6y in parents with P-CHD and 64±3y in parents with NP-CHD. These groups had similar prevalence of hypertension, NIDDM and dyslipidemia. History of cigarette smoking was positive in 74% of parents with P-CHD and in 45% of parents with NP-CHD (p<0.001).The offspring were basically healthy young subjects (age 33±5.8; females 51%, never smokers 61%, normal weight 74%; normotensive 89%, LDL-C130 66%). As expected, IMT was significantly lower in females and directly related to age. Progeny of P-CHD and NP-CHD had similar BP, BMI, TC, LDL-C, HDL-C and TG but the former were younger (28.5±5.4 vs. 32.6±2.3 y, p <0.0001). After data adjustment for sex, age, and smoking habits, Max IMT in offspring of P-CHD subjects was significantly higher than in offspring of NP-CHD (0.94±0.02 vs. 0.86±0.03, p=0.048). No differences in IMT measures were found when the progeny of CHD patients with or without history of smoking were compared Conclusions parental earliness of CHD is a determinant of carotid Max IMT in the progeny whereas parental history of smoking is not. Funding Centro Cardiologico Monzino. Italian Ministry of HealthFile | Dimensione | Formato | |
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