The plasma membrane (PM) sphingolipid composition is the result of a series of well-known metabolic pathways comprising neobiosynthesis in the endoplasmic reticulum and in the Golgi apparatus followed by vesicular delivery to the plasma membrane, membrane turnover with final catabolism in lysosomes, and shedding of membrane components. In addition to this, the head group of PM sphingolipids can be opportunely modified by the action of PM associated hydrolases and transferases. The number of enzymes for glycosphingolipid metabolism that have been shown to be associated with the plasma membrane and the information on their properties are growing very rapidly. In this review, we will focus on the possible role and on the involvement of the plasma membrane-associated glycohydrolases in modulating cell functions.

Fine tuning of cell functions through remodeling of glycosphingolipids by plasma membrane-associated glycohydrolases / S. Sonnino, M. Aureli, N. Loberto, V.L. Chigorno, A.E.G. Prinetti. - In: FEBS LETTERS. - ISSN 0014-5793. - 584:9(2010), pp. 1914-1922. [10.1016/j.febslet.2009.11.020]

Fine tuning of cell functions through remodeling of glycosphingolipids by plasma membrane-associated glycohydrolases

S. Sonnino
Primo
;
M. Aureli
Secondo
;
N. Loberto;V.L. Chigorno
Penultimo
;
A.E.G. Prinetti
Ultimo
2010

Abstract

The plasma membrane (PM) sphingolipid composition is the result of a series of well-known metabolic pathways comprising neobiosynthesis in the endoplasmic reticulum and in the Golgi apparatus followed by vesicular delivery to the plasma membrane, membrane turnover with final catabolism in lysosomes, and shedding of membrane components. In addition to this, the head group of PM sphingolipids can be opportunely modified by the action of PM associated hydrolases and transferases. The number of enzymes for glycosphingolipid metabolism that have been shown to be associated with the plasma membrane and the information on their properties are growing very rapidly. In this review, we will focus on the possible role and on the involvement of the plasma membrane-associated glycohydrolases in modulating cell functions.
Settore BIO/10 - Biochimica
2010
Article (author)
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/139394
Citazioni
  • ???jsp.display-item.citation.pmc??? 10
  • Scopus 42
  • ???jsp.display-item.citation.isi??? 38
social impact