Although computational and experimental models for cell migration and dynamics on two-dimensional (2D) substrata have described how various molecular and cellular properties and biochemical processes are integrated to accomplish cell functions, biologists are increasingly turning to threedimensional cell cultures, where they are discovering biological activities that more closely mirror what happens in living organisms. In fact, the in situ environment of a cell in living organism has a threedimensional architecture. This “new dimension” may represent a challenge in mathematical and computational modelling in order to better understand physiological and biochemical processes. We report here two examples regarding phenomenological description of early stages of vascular network assembly and, respectively, of olfactory system in embryogenesis.
New dimension in Biology: two examples of 3D phenomenological models / G. Naldi. - In: OBERWOLFACH REPORTS. - ISSN 1660-8933. - (2006).
New dimension in Biology: two examples of 3D phenomenological models
G. NaldiPrimo
2006
Abstract
Although computational and experimental models for cell migration and dynamics on two-dimensional (2D) substrata have described how various molecular and cellular properties and biochemical processes are integrated to accomplish cell functions, biologists are increasingly turning to threedimensional cell cultures, where they are discovering biological activities that more closely mirror what happens in living organisms. In fact, the in situ environment of a cell in living organism has a threedimensional architecture. This “new dimension” may represent a challenge in mathematical and computational modelling in order to better understand physiological and biochemical processes. We report here two examples regarding phenomenological description of early stages of vascular network assembly and, respectively, of olfactory system in embryogenesis.Pubblicazioni consigliate
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