Mutations of the c-kit gene have been reported in myeloproliferative disorders. We describe here a case of Ph + (b2a2) chronic myelogenous leukemia that, during the course of disease, showed an unusual bone marrow mast-cell infiltration. A mutational screening for the c-kit gene, performed on DNA routinely cryopreserved during the follow-up, evidenced the D816Y-activating mutation as an additional genetic abnormality. Treatment with imatinib mesylate resulted in a substantial decrease of the BCR-ABL/ABL ratio and in the absence of c-kit mutation. It is likely that the superimposed c-kit mutation, in this case, may account for the transient bone marrow mastocytosis.
Chronic myelogenous leukemia with acquired c-kit activating mutation and transient bone marrow mastocytosis / R. Cairoli, G. Grillo, A. Beghini, G. Cornacchini, L. Larizza, E. Morra. - In: HEMATOLOGY JOURNAL. - ISSN 1466-4860. - 5:3(2004), pp. 273-275.
|Titolo:||Chronic myelogenous leukemia with acquired c-kit activating mutation and transient bone marrow mastocytosis|
LARIZZA, LIDIA (Penultimo)
|Settore Scientifico Disciplinare:||Settore MED/03 - Genetica Medica|
Settore BIO/11 - Biologia Molecolare
|Data di pubblicazione:||2004|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1038/sj.thj.6200348|
|Appare nelle tipologie:||01 - Articolo su periodico|