We present the synthesis of trastuzumab-functionalized pegylated iron oxide nanoparticles and provide an FTIR-based approach to gain a direct evidence of the actual conservation of the native structure of conjugated antibody. Their target-selectivity to specific cancer cell receptors has been also assessed.
Investigating the structural biofunctionality of antibodies conjugated to magnetic nanoparticles / E. Occhipinti, P.V.. - In: NANOSCALE. - ISSN 2040-3364. - 3:2(2011 Feb), pp. 387-390. [10.1039/c0nr00436g]
Investigating the structural biofunctionality of antibodies conjugated to magnetic nanoparticles
P. VerderioCo-primo
;S. Mazzucchelli;
2011
Abstract
We present the synthesis of trastuzumab-functionalized pegylated iron oxide nanoparticles and provide an FTIR-based approach to gain a direct evidence of the actual conservation of the native structure of conjugated antibody. Their target-selectivity to specific cancer cell receptors has been also assessed.
| File | Dimensione | Formato | |
|---|---|---|---|
|
Occhipinti 2011.pdf
accesso riservato
Tipologia:
Publisher's version/PDF
Licenza:
Nessuna licenza
Dimensione
244.07 kB
Formato
Adobe PDF
|
244.07 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
Pubblicazioni consigliate
I metadati presenti in AIR sono rilasciati con licenza CCO mentre i file delle pubblicazioni sono rilasciati con licenza CC BY-SA, salvo diversa indicazione. In caso di violazione di copyright, contattare l'assistenza di AIR
