Chromatin architecture study through sequencing-based bioinformatic approaches

"Presented at the 2026 Experimental Medicine PhD Retreat (University of Milan), this talk provided an overview of chromatin architecture and current sequencing-based technologies used to investigate genome organization across multiple scales, ranging from local chromatin accessibility to higher-order nuclear compartmentalization. The presentation further examined how structural alterations in chromatin organization contribute to lymphocyte activation and dysfunction, highlighting the critical role of nuclear architecture in immune regulation and disease pathogenesis.