Analysis of T cells treated with bisphenol A (BPA) and its analogues revealed a dose-dependent impact on lymphocyte differentiation into Th1, Th2, and Th17 subsets, as assessed by flow cytometry and cytokine profiling. The highest concentration of each compound inhibited cell proliferation (CFSE assay) without inducing cytotoxicity, and was associated with reduced intracellular (FACS) and extracellular (ELISA) cytokine production.
Immunomodulatory effects of bisphenols: in vitro evidence of human T cell proliferation and differentiation / F.C. Passoni, M. Iulini, V. Galbiati, E. Corsini. 12. ITCASS-ERGED meeting Strasburgo 2026.
Immunomodulatory effects of bisphenols: in vitro evidence of human T cell proliferation and differentiation
F.C. Passoni;M. Iulini;V. Galbiati;E. Corsini
2026
Abstract
Analysis of T cells treated with bisphenol A (BPA) and its analogues revealed a dose-dependent impact on lymphocyte differentiation into Th1, Th2, and Th17 subsets, as assessed by flow cytometry and cytokine profiling. The highest concentration of each compound inhibited cell proliferation (CFSE assay) without inducing cytotoxicity, and was associated with reduced intracellular (FACS) and extracellular (ELISA) cytokine production.
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