Dry eye disease (DED) is a common condition of the ocular surface that affects tens of millions of people worldwide. It is often characterized by decreased tear production or increased evaporation, resulting in a wide range of signs and symptoms. This review provides a comprehensive analysis of the literature related to DED, detailing causes, diagnostic tests, and medical management. Several mechanisms contribute to the maintenance of the physiological integrity of the ocular surface, and their dysfunction may result in noticeable symptoms. Accurate diagnosis is therefore essential, even when physiological function is only minimally impaired or no clear pathological signs are present. The review emphasizes the importance of addressing the underlying causes through a combination of treatment options, lifestyle changes, and enhanced communication between patients and healthcare providers to break the cycle of inflammation and tear instability. It aims to raise awareness among patients, healthcare professionals, and researchers regarding the diagnosis and treatment of DED, while also highlighting recent advancements and future challenges in its management.

Dry Eye Disease: From Causes to Patient Care and Clinical Collaboration-A Narrative Review / P. Aragona, S. Barabino, A. Di Zazzo, G. Giannaccare, E. Villani, F. Aiello, E. Antoniazzi, S. Bonini, E. Cantera, G. Carlini, C. Chierego, R. Colabelli, R. Fasciani, A. Franch, G. Gabbriellini, C.M.R. Gagliano, A. Leonardi, A. Macrì, R. Mencucci, L. Mosca, V. Orfeo, A. Pinna, A. Pocobelli, R. Protti, P. Rama, L. Rania, M. Rechichi, P. Rubino, A. Russo, V. Scorcia, L. Spadea, M. Trentadue, S. Troisi, P. Versura, M. Rolando. - In: OPHTHALMOLOGY AND THERAPY. - ISSN 2193-8245. - 14:7(2025 Jul), pp. 1411-1428. [10.1007/s40123-025-01161-8]

Dry Eye Disease: From Causes to Patient Care and Clinical Collaboration-A Narrative Review

E. Villani;
2025

Abstract

Dry eye disease (DED) is a common condition of the ocular surface that affects tens of millions of people worldwide. It is often characterized by decreased tear production or increased evaporation, resulting in a wide range of signs and symptoms. This review provides a comprehensive analysis of the literature related to DED, detailing causes, diagnostic tests, and medical management. Several mechanisms contribute to the maintenance of the physiological integrity of the ocular surface, and their dysfunction may result in noticeable symptoms. Accurate diagnosis is therefore essential, even when physiological function is only minimally impaired or no clear pathological signs are present. The review emphasizes the importance of addressing the underlying causes through a combination of treatment options, lifestyle changes, and enhanced communication between patients and healthcare providers to break the cycle of inflammation and tear instability. It aims to raise awareness among patients, healthcare professionals, and researchers regarding the diagnosis and treatment of DED, while also highlighting recent advancements and future challenges in its management.
Dry eye disease; Hyperosmolarity; Inflammation; Ocular surface diseases; Patients; Quality of life; Symptoms; Therapy
Settore MEDS-17/A - Malattie dell'apparato visivo
lug-2025
28-mag-2025
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/1243515
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