AMPA receptor ion channels are of paramount importance for postsynaptic excitation. Several reports demonstrate that AMPA receptors are present in the presynaptic compartment and point to a role of these receptors in the modulation of presynaptic function. We discuss here the possibility that not only ion influx through the receptor, but also biochemical cascades, activated by ligand binding and independent from ion flux, might contribute to AMPA mediated presynaptic modulation.
Presynaptic AMPA receptors : more than just ion channels? / U. Schenk, M. Matteoli. - In: BIOLOGY OF THE CELL. - ISSN 0248-4900. - 96:4(2004), pp. 257-260.
Presynaptic AMPA receptors : more than just ion channels?
M. MatteoliUltimo
2004
Abstract
AMPA receptor ion channels are of paramount importance for postsynaptic excitation. Several reports demonstrate that AMPA receptors are present in the presynaptic compartment and point to a role of these receptors in the modulation of presynaptic function. We discuss here the possibility that not only ion influx through the receptor, but also biochemical cascades, activated by ligand binding and independent from ion flux, might contribute to AMPA mediated presynaptic modulation.
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