We analyzed mutations in the 5′ non-coding region of the BCL-6 gene in 46 cases of primary cutaneous B-cell lymphomas (PCBCL), using a polymerase chain reaction single strand conformation polymorphism (PCR-SSCP) method. The results indicate that PCBCL display a low frequency of mutations and support a marginal zone B-cell origin for most of these neoplasms.
BCL-6 gene mutations in primary cutaneous B-cell lymphomas / U. Gianelli, A. Cerri, B. Cassani, L. Moneghini, P.R. Raviele, E. Berti, S. Bosari. - In: HAEMATOLOGICA. - ISSN 0390-6078. - 89:5(2004), pp. 624-626.
BCL-6 gene mutations in primary cutaneous B-cell lymphomas
U. Gianelli;A. Cerri;E. Berti;S. Bosari
2004
Abstract
We analyzed mutations in the 5′ non-coding region of the BCL-6 gene in 46 cases of primary cutaneous B-cell lymphomas (PCBCL), using a polymerase chain reaction single strand conformation polymorphism (PCR-SSCP) method. The results indicate that PCBCL display a low frequency of mutations and support a marginal zone B-cell origin for most of these neoplasms.
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