Botulinum toxins are metalloproteases that act inside nerve terminals and block neurotransinitter release via their activity directed specifically on SNARE proteins. This review summarizes data on botulinuin toxin modes of binding, sites of action, and biochemical activities. Their use in cell biology and neuroscience is considered, as well as their therapeutic utilization in human diseases characterized by hyperfunction of cholinergic terminals. (c) 2005 Elsevier Inc. All rights reserved.
Internalization and mechanism of action of clostridial toxins in neurons / C. Grumelli, C. Verderio, D. Pozzi, O. Rossetto, C. Montecucco, M. Matteoli. - In: NEUROTOXICOLOGY. - ISSN 0161-813X. - 26:5(2005), pp. 761-767.
Internalization and mechanism of action of clostridial toxins in neurons
M. MatteoliUltimo
2005
Abstract
Botulinum toxins are metalloproteases that act inside nerve terminals and block neurotransinitter release via their activity directed specifically on SNARE proteins. This review summarizes data on botulinuin toxin modes of binding, sites of action, and biochemical activities. Their use in cell biology and neuroscience is considered, as well as their therapeutic utilization in human diseases characterized by hyperfunction of cholinergic terminals. (c) 2005 Elsevier Inc. All rights reserved.
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