To address the lack of data on male genital tract penetration of CAB-LA PrEP, seminal plasma was collected at days 3, 7, 28, 84, and 140 and analyzed by LC-MS/MS. CAB was detectable in 71% of samples at day 3, 73% at day 7, and 92% at day 28, with all samples quantifiable at days 84 and 140. Seminal-to-blood plasma ratios remained low but proportional to systemic exposure, indicating sustained seminal CAB exposure.
Seminal plasma concentrations of long-acting cabotegravir in men receiving HIV pre-exposure prophylaxis / D. Moschese, C. Fusetti, S. Lazzarin, A. Giacomelli, V. Mazzotta, D. Cattaneo, A. D'Avolio, F. Caruso, D. Maddalena, F. Petri, A. Antinori, C. Gervasoni, A. Gori, M. Vittoria Cossu. - In: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. - ISSN 0066-4804. - (2026), pp. e0016526.1-e0016526.4. [Epub ahead of print] [10.1128/aac.00165-26]
Seminal plasma concentrations of long-acting cabotegravir in men receiving HIV pre-exposure prophylaxis
D. Moschese
Primo
;C. FusettiSecondo
;S. Lazzarin;A. Giacomelli;D. Cattaneo;F. Caruso;D. Maddalena;F. Petri;A. GoriPenultimo
;
2026
Abstract
To address the lack of data on male genital tract penetration of CAB-LA PrEP, seminal plasma was collected at days 3, 7, 28, 84, and 140 and analyzed by LC-MS/MS. CAB was detectable in 71% of samples at day 3, 73% at day 7, and 92% at day 28, with all samples quantifiable at days 84 and 140. Seminal-to-blood plasma ratios remained low but proportional to systemic exposure, indicating sustained seminal CAB exposure.
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