The healthcare sector increasingly relies on digital infrastructures to manage large volumes of sensitive medical data. Ensuring integrity, controlled access, interoperability, and auditability remains a fundamental challenge. We propose BlockHealth, a hybrid blockchain-based framework that integrates smart contracts, distributed databases, and proxy re-encryption to support secure and verifiable healthcare data management. The system leverages Ethereum and NFT-based identities for access control, Merkle-tree commitment for tamper-evident integrity verification, and a distributed Cassandra storage layer for scalable and regulation-compliant off-chain data management. Proxy re-encryption enables secure delegation of access without exposing private keys, while a coordinating API service ensures interoperability with existing hospital infrastructures. Our evaluation demonstrates the feasibility and efficiency of core operations — including hashing, on-chain commits, and re-encryption — indicating that the proposed framework can provide a practical balance among verifiability, performance, and deployability in realistic healthcare environments.
BlockHealth: a Blockchain based Framework for Secure and Efficient Healthcare Data Management / C. Braghin, S. Cimato, S. Pesci, E. Riccobene. - In: BLOCKCHAIN: RESEARCH AND APPLICATIONS. - ISSN 2096-7209. - (2026). [Epub ahead of print] [10.1016/j.bcra.2026.100468]
BlockHealth: a Blockchain based Framework for Secure and Efficient Healthcare Data Management
C. BraghinPrimo
;S. CimatoSecondo
;S. PesciPenultimo
;E. RiccobeneUltimo
2026
Abstract
The healthcare sector increasingly relies on digital infrastructures to manage large volumes of sensitive medical data. Ensuring integrity, controlled access, interoperability, and auditability remains a fundamental challenge. We propose BlockHealth, a hybrid blockchain-based framework that integrates smart contracts, distributed databases, and proxy re-encryption to support secure and verifiable healthcare data management. The system leverages Ethereum and NFT-based identities for access control, Merkle-tree commitment for tamper-evident integrity verification, and a distributed Cassandra storage layer for scalable and regulation-compliant off-chain data management. Proxy re-encryption enables secure delegation of access without exposing private keys, while a coordinating API service ensures interoperability with existing hospital infrastructures. Our evaluation demonstrates the feasibility and efficiency of core operations — including hashing, on-chain commits, and re-encryption — indicating that the proposed framework can provide a practical balance among verifiability, performance, and deployability in realistic healthcare environments.| File | Dimensione | Formato | |
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1-s2.0-S2096720926000308-main.pdf
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