Experience with transcatheter aortic valve replacement (TAVR) techniques is rapidly expanding, driven primarily by technological advances in device design and positive clinical outcomes across various patient populations. Paravalvular leak (PVL), a known complication of TAVR associated with less favorable clinical outcomes, has progressively been addressed with improvements in the sealing mechanisms of transcatheter heart valves and with the development of strategies aimed at mitigating or even eliminating its clinical impact. The aim of this review is to provide a comprehensive overview of PVL after TAVR, examining etiology, risk factors, diagnostic approaches, and management strategies. By synthesizing current evidence and highlighting recent advances, the aim is to contribute to ongoing efforts to optimize TAVR outcomes and reduce the burden of PVL in this rapidly evolving field.

Paravalvular Regurgitation After Transcatheter Aortic Valve Replacement : Incidence, Mechanism, and Interventional Management / M. Biroli, G.H.L. Tang, M. Taramasso, F. De Marco, G. Pontone, F. Biancari, L. Fusini, M. Muratori, F. Maisano, M. Gennari. - In: JACC. CARDIOVASCULAR INTERVENTIONS. - ISSN 1876-7605. - 19:4(2026 Feb 23), pp. 401-421. [10.1016/j.jcin.2025.12.014]

Paravalvular Regurgitation After Transcatheter Aortic Valve Replacement : Incidence, Mechanism, and Interventional Management

M. Biroli
Primo
;
F. De Marco;G. Pontone;L. Fusini;M. Gennari
2026

Abstract

Experience with transcatheter aortic valve replacement (TAVR) techniques is rapidly expanding, driven primarily by technological advances in device design and positive clinical outcomes across various patient populations. Paravalvular leak (PVL), a known complication of TAVR associated with less favorable clinical outcomes, has progressively been addressed with improvements in the sealing mechanisms of transcatheter heart valves and with the development of strategies aimed at mitigating or even eliminating its clinical impact. The aim of this review is to provide a comprehensive overview of PVL after TAVR, examining etiology, risk factors, diagnostic approaches, and management strategies. By synthesizing current evidence and highlighting recent advances, the aim is to contribute to ongoing efforts to optimize TAVR outcomes and reduce the burden of PVL in this rapidly evolving field.
TAVR; aortic regurgitation; balloon-expandable valve; interventional management; paravalvular leak; self-expanding valve
Settore MEDS-07/B - Malattie dell'apparato cardiovascolare
23-feb-2026
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/1231956
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