Formosulfathiazole (FSTz) is a synthetic active pharmaceutical ingredient (API) prepared by condensation of sulfathiazole with formaldehyde. Originally described for the first time in 1948, it is currently used for the treatment of bacterial and protozoal infections in cattle and pets, acting as a prodrug slowly releasing the sulfamidic sulfathiazole and formaldehyde. A systematic analysis of FSTz allowed to revise the originally believed undefined polymeric structure and uncovered the intriguing cyclophane skeleton of a well-defined cyclodimeric condensation product.
Formosulfathiazole: A Structural Revision / C. Maestri, T. Grell, F. Travagin, C.R. Göb, M. Castaldi, I. Miletto, G. Paul, S. Zampini, M. Vandone, V. Colombo, G.B. Giovenzana. - In: CHEMPLUSCHEM. - ISSN 2192-6506. - 90:11(2025 Sep 05), pp. e202500406.1-e202500406.5. [10.1002/cplu.202500406]
Formosulfathiazole: A Structural Revision
T. Grell;M. Vandone
;V. Colombo
Penultimo
;
2025
Abstract
Formosulfathiazole (FSTz) is a synthetic active pharmaceutical ingredient (API) prepared by condensation of sulfathiazole with formaldehyde. Originally described for the first time in 1948, it is currently used for the treatment of bacterial and protozoal infections in cattle and pets, acting as a prodrug slowly releasing the sulfamidic sulfathiazole and formaldehyde. A systematic analysis of FSTz allowed to revise the originally believed undefined polymeric structure and uncovered the intriguing cyclophane skeleton of a well-defined cyclodimeric condensation product.
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