Recent advances in the study of TAR DNA-binding protein 43 (TDP-43) have significantly improved the understanding of its role across a spectrum of neurodegenerative diseases, including amyotrophic lateral sclerosis and frontotemporal lobar degeneration. This presentation provides an overview of the latest findings on TDP-43 pathology, focusing on mechanisms of protein misfolding, aggregation, and propagation, as well as their contribution to neuronal dysfunction and disease progression.
TDP-43 Seed amplification assay / M.B. Bacinoglu, F. Moda. I's on TDP-43: initiatives on TDP-43 proteinopathies conference Parigi 2025.
TDP-43 Seed amplification assay
M.B. Bacinoglu
Primo
;F. Moda
2025
Abstract
Recent advances in the study of TAR DNA-binding protein 43 (TDP-43) have significantly improved the understanding of its role across a spectrum of neurodegenerative diseases, including amyotrophic lateral sclerosis and frontotemporal lobar degeneration. This presentation provides an overview of the latest findings on TDP-43 pathology, focusing on mechanisms of protein misfolding, aggregation, and propagation, as well as their contribution to neuronal dysfunction and disease progression.
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