A core outcome set for locoregional treatment reporting in neoadjuvant systemic breast cancer treatment trials

Potter, S.; Avery, K.; Ahmed, R.; De Boniface, J.; Chatterjee, S.; Dodwell, D.; Dubsky, P.; Federmann, J.; Finestone, S.; Gnant, M.; Hlauschek, D.; Iwata, H.; Jiang, M.Y.; Kaidar-Person, O.; Lee, H.; Mackenzie, M.; Meyn, A.; Poortmans, P.; Poulakaki, F.; Richardson, A.L.; Sepulveda, K.A.; Spillane, A.J.; Thompson, A.M.; Werutsky, G.; Wittmann, P.; Wright, J.L.; Zdenkowski, N.; Cowan, K.; Mcintosh, S.A.; Null, N.; Abbott, N.; Abdah-Bortnyak, R.; Abdelwahab, K.; Haris, P.A.; Aebi, S.; Agarwal, G.; Albacar, C.; Algara, M.; Aligizakis, E.; Garcia, R.; Amirov, N.; Amreen, S.; Ancao, M.B.; Aragón, S.; Arikan, A.E.; Aristei, C.; Asif, F.; Aznar, M.; Backianathan, S.; Bando, H.; Banys-Paluchowski, M.; Barrette, V.; Barry, P.; Becherini, C.; Berardi, R.; Bernstein-Molho, R.; Berpan, A.; Beurer, B.; Bhattacharya, I.; Bjelic-Radisic, V.; Boersma, L.; Bonci, E.; Bonetti, A.; Borg, E.; Branson, T.; Brown-Glaberman, U.; Bucci, E.O.; Bueno, C.; Bülbüloğlu, G.C.; Burnette, B.; Cain, H.; Campbell, B.; Cano-Jimenez, A.; Ömer-Cantürk, A.; Peterko, A.C.; Carmichael, A.; Castillo, C.; Chan, N.; Chen, S.; Chiu, M.K.L.; Choraria, A.; Claros, J.; Collins, J.; Conde-Herrero, V.; Constantinidou, A.; Coopey, S.; Copson, E.; Corradini, S.; Corsi, F.; Cortes, P.; Crawford, K.; Cretella, E.; Cruz, J.; Cutress, R.; Daiuto, M.; Daskalova, I.; Davies, M.; Caluwé, A.D.; Pinta, C.D.L.; Berron, S.D.B.; Delaney, G.P.; Deschuymer, S.; Micco, R.D.; Diaz-Gavela, A.A.; Dimitrov, D.; Dogan, L.; Dougoud-Chauvin, V.; Douvetzemis, S.; Dragoumis, D.; Duane, F.; Ebner, F.; Edge, J.; Eiriz, I.; Elder, E.; Elfgen, C.; Elsberger, B.; Eraso, A.; Erel, S.; Esakia, T.; Espinosa-Bravo, M.; Estevez-Diz, M.D.P.; Fabiano, V.Y.; Fahmy, W.; Fancellu, A.; Fernandez, I.; Fernández-Morales, L.; Ferreiro, J.; Fiorica, F.; Fougo, J.; Franceschini, G.; Fuentes, H.; Garach, N.; Gasparri, M.L.; Generali, D.; Ghilli, M.; Gil-Gil, M.; Gomez, H.L.; Gössling, G.; Grobmyer, S.; Großmann, C.; Gunay, S.; Hadar, T.; Hajjaji, N.; Hariharan, N.; Harris, G.; Hegarty, G.; Heidinger, M.; Hijal, T.; Hsu, C.; Hubbard, T.; Huda, F.; Huscher, A.; Ikram, R.; Illarramendi, J.J.; Irwin, G.; Jagsi, R.; James, M.; Jerusalem, G.; Jerzak, K.; Johnson, C.; Johnson, N.; Jung, K.; Jung, J.; Chanthar, V.; Kadayaprath, G.; Polat, A.K.; Kang, T.; Kanyadhara, L.K.; Çakmak, G.K.; Karakatsanis, A.; Karamanliev, M.; Khan, M.M.; Kihn-Alarcón, A.; Kipps, E.; Kirwan, C.; Klein, E.; Hyun Soo, K.; Konsoulova, A.; Konstantis, A.; Kontos, M.; Kretsi, A.; Krug, D.; Kunkler, I.; Laws, S.; Leal, S.; Lee, J.; Liang, R.; Valenti, E.L.; Ludwig, M.; Lüftner, D.; Luzi, M.; Machiels, M.; Macinnes, E.; Macpherson, I.; Madeira, P.; Maduro, J.; Makris, G.M.; Mando, P.; Mansell, J.; Mantilla, W.; Maraldo, M.; Marcou, Y.; Margenthaler, J.; Marta, G.; Martel, K.; Marti, C.; Martin-Quesada, A.I.; Martos, T.; Masannat, Y.; Masiello, V.; Masuda, N.; Mau, C.I.; Maulik, S.; Meattini, I.; Meduri, B.; Meretoja, T.; Meterissian, S.; Minisini, A.M.; Misra, S.; Montero, A.; Morgan, J.; Migueláñez, T.M.; Munzone, E.; Murawa, D.; Namiq, K.; Sánchez, M.A.N.; Narui, K.; Nguyen, T.; Nikolic, D.; Nikopoulou, A.; O'Neill, C.; O'Reilly, S.; Oikonomou, I.; Bagge, R.O.; Ferrando, A.O.; Papadopoulos, L.; Pascual, J.; Pasquier, D.; Pellegrini, A.; Peretz-Yablonski, T.; Segura, C.P.; Piñero-Madrona, A.; Pogoda, K.; Popescu, R.; Poppe, M.; Porpiglia, M.; Portik, D.; Moura, J.F.P.; Provenzano, E.; Puchinskaya, M.; Putora, P.M.; Radhakrishnan, V.; Rahim, I.U.; Ramiah, D.; Rao, S.; Ratosa, I.; Razis, E.; Read, R.; Rebaza, L.; Redfern, A.; Reinert, T.; Retamales, J.; Riis, M.; Roberts, N.; Rocco, N.; Rojas, B.; Roshanlall, C.; Rosset, L.; Rovera, F.; Rubio, I.T.; Russell, N.; Ruyssers, N.; Ryu, J.M.; Sackey, H.; Saha, S.; Salinas, J.E.; Sánchez-Méndez, J.I.; Savva, C.; Scardina, L.; Serra, M.; Setakornnukul, J.; Shanthilal, M.; Sharawy, I.; Sharma, S.; Shenoy, S.; Shetty, P.S.; Shoshkova, M.; Sibbering, M.; Sidiropoulou, Z.; Silva, A.; Simcock, R.; Sirohi, B.; Smith, F.; Snook, K.; De Celis, E.S.P.; Spanheimer, P.; Stranzl, H.; Stuart, K.; Suga, Y.; Susini, T.; Swinden, M.; Tandon, M.; Tavoletta, M.S.; Taylor, D.; Liutti, V.T.; Tezcanli, E.; Thaweerat, W.; Thomson, J.; Thorat, M.; Tsiatas, M.; Tsoutsou, P.; Tvedskov, T.; Ueno, T.; Vaidya, J.; Valachis, A.; Berkmortel, F.V.D.; Hage, J.V.D.; Duijnhoven, F.V.; Van Maaren, M.C.; Vandermeulen, A.; Vázquez-Barreiro, B.; Velu, U.; Venkitaraman, R.; Vidal-Sicart, S.; Vohra, L.; Voutsadakis, I.; Wadasadawala, T.; Walker, M.; Wapnir, I.; Warnberg, F.; Wiebe, E.; Wong, S.; Wyld, L.; Kumar, S.; Yeh, J.; Yiallourou, A.; Youn, H.J.; Žatecký, J.; Cobos, G.Z.; Zeko, A.; Zivkovic, M.; Zope, A.

doi:10.1038/s41523-025-00824-w

Accurate information about locoregional breast cancer treatments following neoadjuvant systemic therapy (NST) is essential for meaningful interpretation of oncological outcomes but reporting is currently poor. We developed a core outcome set (COS) to improve the quality and consistency of locoregional outcome reporting in breast cancer NST trials. The COS was developed in three phases according to COS-STAD guidance, with the generation of a list of relevant outcome domains, prioritisation of outcomes through two rounds of an international online multi-stakeholder Delphi survey and a consensus meeting. 159 unique locoregional outcomes were classified into 101 outcome domains for inclusion in the Delphi survey, which was completed by 470 international professionals. The final 15-item COS, which included the pre-NST surgical plan, details of surgery performed following completion of treatment and details of radiation therapy, was agreed at an in-person consensus meeting. Widespread COS implementation will improve the quality and value of future NST trials.

A core outcome set for locoregional treatment reporting in neoadjuvant systemic breast cancer treatment trials / S. Potter, K. Avery, R. Ahmed, J. De Boniface, S. Chatterjee, D. Dodwell, P. Dubsky, J. Federmann, S. Finestone, M. Gnant, D. Hlauschek, H. Iwata, M.Y. Jiang, O. Kaidar-Person, H. Lee, M. Mackenzie, A. Meyn, P. Poortmans, F. Poulakaki, A.L. Richardson, K.A. Sepulveda, A.J. Spillane, A.M. Thompson, G. Werutsky, P. Wittmann, J.L. Wright, N. Zdenkowski, K. Cowan, S.A. Mcintosh, N. Null, N. Abbott, R. Abdah-Bortnyak, K. Abdelwahab, P.A. Haris, S. Aebi, G. Agarwal, C. Albacar, M. Algara, E. Aligizakis, R. Garcia, N. Amirov, S. Amreen, M.B. Ancao, S. Aragón, A.E. Arikan, C. Aristei, F. Asif, M. Aznar, S. Backianathan, H. Bando, M. Banys-Paluchowski, V. Barrette, P. Barry, C. Becherini, R. Berardi, R. Bernstein-Molho, A. Berpan, B. Beurer, I. Bhattacharya, V. Bjelic-Radisic, L. Boersma, E. Bonci, A. Bonetti, E. Borg, T. Branson, U. Brown-Glaberman, E.O. Bucci, C. Bueno, G.C. Bülbüloğlu, B. Burnette, H. Cain, B. Campbell, A. Cano-Jimenez, A. Ömer-Cantürk, A.C. Peterko, A. Carmichael, C. Castillo, N. Chan, S. Chen, M.K.L. Chiu, A. Choraria, J. Claros, J. Collins, V. Conde-Herrero, A. Constantinidou, S. Coopey, E. Copson, S. Corradini, F. Corsi, P. Cortes, K. Crawford, E. Cretella, J. Cruz, R. Cutress, M. Daiuto, I. Daskalova, M. Davies, A.D. Caluwé, C.D.L. Pinta, S.D.B. Berron, G.P. Delaney, S. Deschuymer, R.D. Micco, A.A. Diaz-Gavela, D. Dimitrov, L. Dogan, V. Dougoud-Chauvin, S. Douvetzemis, D. Dragoumis, F. Duane, F. Ebner, J. Edge, I. Eiriz, E. Elder, C. Elfgen, B. Elsberger, A. Eraso, S. Erel, T. Esakia, M. Espinosa-Bravo, M.D.P. Estevez-Diz, V.Y. Fabiano, W. Fahmy, A. Fancellu, I. Fernandez, L. Fernández-Morales, J. Ferreiro, F. Fiorica, J. Fougo, G. Franceschini, H. Fuentes, N. Garach, M.L. Gasparri, D. Generali, M. Ghilli, M. Gil-Gil, H.L. Gomez, G. Gössling, S. Grobmyer, C. Großmann, S. Gunay, T. Hadar, N. Hajjaji, N. Hariharan, G. Harris, G. Hegarty, M. Heidinger, T. Hijal, C. Hsu, T. Hubbard, F. Huda, A. Huscher, R. Ikram, J.J. Illarramendi, G. Irwin, R. Jagsi, M. James, G. Jerusalem, K. Jerzak, C. Johnson, N. Johnson, K. Jung, J. Jung, V. Chanthar, G. Kadayaprath, A.K. Polat, T. Kang, L.K. Kanyadhara, G.K. Çakmak, A. Karakatsanis, M. Karamanliev, M.M. Khan, A. Kihn-Alarcón, E. Kipps, C. Kirwan, E. Klein, H.S. Ko, A. Konsoulova, A. Konstantis, M. Kontos, A. Kretsi, D. Krug, I. Kunkler, S. Laws, S. Leal, J. Lee, R. Liang, E.L. Valenti, M. Ludwig, D. Lüftner, M. Luzi, M. Machiels, E. Macinnes, I. Macpherson, P. Madeira, J. Maduro, G.M. Makris, P. Mando, J. Mansell, W. Mantilla, M. Maraldo, Y. Marcou, J. Margenthaler, G. Marta, K. Martel, C. Marti, A.I. Martin-Quesada, T. Martos, Y. Masannat, V. Masiello, N. Masuda, C.I. Mau, S. Maulik, I. Meattini, B. Meduri, T. Meretoja, S. Meterissian, A.M. Minisini, S. Misra, A. Montero, J. Morgan, T.M. Migueláñez, E. Munzone, D. Murawa, K. Namiq, M.A.N. Sánchez, K. Narui, T. Nguyen, D. Nikolic, A. Nikopoulou, C. O'Neill, S. O'Reilly, I. Oikonomou, R.O. Bagge, A.O. Ferrando, L. Papadopoulos, J. Pascual, D. Pasquier, A. Pellegrini, T. Peretz-Yablonski, C.P. Segura, A. Piñero-Madrona, K. Pogoda, R. Popescu, M. Poppe, M. Porpiglia, D. Portik, J.F.P. Moura, E. Provenzano, M. Puchinskaya, P.M. Putora, V. Radhakrishnan, I.U. Rahim, D. Ramiah, S. Rao, I. Ratosa, E. Razis, R. Read, L. Rebaza, A. Redfern, T. Reinert, J. Retamales, M. Riis, N. Roberts, N. Rocco, B. Rojas, C. Roshanlall, L. Rosset, F. Rovera, I.T. Rubio, N. Russell, N. Ruyssers, J.M. Ryu, H. Sackey, S. Saha, J.E. Salinas, J.I. Sánchez-Méndez, C. Savva, L. Scardina, M. Serra, J. Setakornnukul, M. Shanthilal, I. Sharawy, S. Sharma, S. Shenoy, P.S. Shetty, M. Shoshkova, M. Sibbering, Z. Sidiropoulou, A. Silva, R. Simcock, B. Sirohi, F. Smith, K. Snook, E.S.P. De Celis, P. Spanheimer, H. Stranzl, K. Stuart, Y. Suga, T. Susini, M. Swinden, M. Tandon, M.S. Tavoletta, D. Taylor, V.T. Liutti, E. Tezcanli, W. Thaweerat, J. Thomson, M. Thorat, M. Tsiatas, P. Tsoutsou, T. Tvedskov, T. Ueno, J. Vaidya, A. Valachis, F.V.D. Berkmortel, J.V.D. Hage, F.V. Duijnhoven, M.C. Van Maaren, A. Vandermeulen, B. Vázquez-Barreiro, U. Velu, R. Venkitaraman, S. Vidal-Sicart, L. Vohra, I. Voutsadakis, T. Wadasadawala, M. Walker, I. Wapnir, F. Warnberg, E. Wiebe, S. Wong, L. Wyld, S. Kumar, J. Yeh, A. Yiallourou, H.J. Youn, J. Žatecký, G.Z. Cobos, A. Zeko, M. Zivkovic, A. Zope. - In: NPJ BREAST CANCER. - ISSN 2374-4677. - 11:1(2025 Oct 28), pp. 116.1-116.10. [10.1038/s41523-025-00824-w]

A core outcome set for locoregional treatment reporting in neoadjuvant systemic breast cancer treatment trials

Potter, Shelley;Avery, Kerry;Ahmed, Rosina;de Boniface, Jana;Chatterjee, Sanjoy;Dodwell, David;Dubsky, Peter;Federmann, Jingjing;Finestone, Sandra;Gnant, Michael;Hlauschek, Dominik;Iwata, Hiroji;Jiang, Michael Y.;Kaidar-Person, Orit;Lee, Han-Byoel;MacKenzie, Mairead;Meyn, Anne;Poortmans, Philip;Poulakaki, Fiorita;Richardson, Andrea L.;Sepulveda, Karla A.;Spillane, Andrew J.;Thompson, Alastair M.;Werutsky, Gustavo;Wittmann, Philipp;Wright, Jean L.;Zdenkowski, Nicholas;Cowan, Katherine;McIntosh, Stuart A.;null, null;Abbott, Nick;Abdah-Bortnyak, Roxolyana;Abdelwahab, Khaled;Haris, Puteri Abdul;Aebi, Stefan;Agarwal, Gaurav;Albacar, Cinta;Algara, Manuel;Aligizakis, Emmanouil;Garcia, Raphael;Amirov, Nikolay;Amreen, Saika;Ancao, María Belén;Aragón, Sofía;Arikan, Akif Enes;Aristei, Cynthia;Asif, Farah;Aznar, Marianne;Backianathan, Selvamani;Bando, Hiroko;Banys-Paluchowski, Maggie;Barrette, Vincent;Barry, Peter;Becherini, Carlotta;Berardi, Rossana;Bernstein-Molho, Rinat;Berpan, Aniwat;Beurer, Björn;Bhattacharya, Indrani;Bjelic-Radisic, Vesna;Boersma, Liesbeth;Bonci, Eduard-Alexandru;Bonetti, Andrea;Borg, Elaine;Branson, Tony;Brown-Glaberman, Ursa;Bucci, Eraldo Oreste;Bueno, Coralia;Bülbüloğlu, Güney Cem;Burnette, Brian;Cain, Henry;Campbell, Beth;Cano-Jimenez, Alicia;Ömer-Cantürk, Alp;Peterko, Ana Car;Carmichael, Amtul;Castillo, Cecilia;Chan, Nancy;Chen, Samantha;Chiu, Matthew Kin Liang;Choraria, Amit;Claros, Juncal;Collins, John;Conde-Herrero, Veronica;Constantinidou, Anastasia;Coopey, Suzanne;Copson, Ellen;Corradini, Stefanie;F. Corsi;Cortes, Paulo;Crawford, Kyle;Cretella, Elisabetta;Cruz, Josefina;Cutress, Ramsey;Daiuto, Massimiliano;Daskalova, Iskra;Davies, Mark;Caluwé, Alex De;Pinta, Carolina De La;Berron, Sonia Del Barca;Delaney, Geoff P.;Deschuymer, Sarah;Micco, Rosa Di;Diaz-Gavela, Ana Aurora;Dimitrov, Dobromir;Dogan, Lutfi;Dougoud-Chauvin, Vérène;Douvetzemis, Stergios;Dragoumis, Dimitrios;Duane, Frances;Ebner, Florian;Edge, Jenny;Eiriz, Inês;Elder, Elisabeth;Elfgen, Constanze;Elsberger, Beatrix;Eraso, Arantxa;Erel, Serap;Esakia, Tamar;Espinosa-Bravo, Martin;Estevez-Diz, Maria Del Pilar;Fabiano, Veronica Yamila;Fahmy, Waleed;Fancellu, Alessandro;Fernandez, Isaura;Fernández-Morales, Luis;Ferreiro, Josefa;Fiorica, Francesco;Fougo, José;Franceschini, Gianluca;Fuentes, Hugo;Garach, Niharika;Gasparri, Maria Luisa;D. Generali;Ghilli, Matteo;Gil-Gil, Miguel;Gomez, Henry Leonidas;Gössling, Gustavo;Grobmyer, Stephen;Großmann, Christoph;Gunay, Semra;Hadar, Tal;Hajjaji, Nawale;Hariharan, Nisha;Harris, Grant;Hegarty, Gemma;Heidinger, Martin;Hijal, Tarek;Hsu, Cary;Hubbard, Thomas;Huda, Farhanul;Huscher, Alessandra;Ikram, Rabia;Illarramendi, Jose Juan;Irwin, Gareth;Jagsi, Reshma;James, Melissa;Jerusalem, Guy;Jerzak, Katarzyna;Johnson, Carol;Johnson, Nathalie;Jung, Kylie;Jung, Ji-Jung;Chanthar, Vishvak;Kadayaprath, Geeta;Polat, Ayfer Kamali;Kang, Taewoo;Kanyadhara, Lohita Krishna;Çakmak, Güldeniz Karadeniz;Karakatsanis, Andreas;Karamanliev, Martin;Khan, Mah Muneer;Kihn-Alarcón, Alba;Kipps, Emma;Kirwan, Cliona;Klein, Evelyn;Ko, Hyun Soo;Konsoulova, Assia;Konstantis, Apostolos;Kontos, Michalis;Kretsi, Antigoni;Krug, David;Kunkler, Ian;Laws, Siobhan;Leal, Sara;Lee, Jeeyeon;Liang, Rhea;Valenti, Elisenda Llabres;Ludwig, Michelle;Lüftner, Diana;Luzi, Manjola;Machiels, Melanie;Macinnes, Emma;Macpherson, Iain;Madeira, Pedro;Maduro, John;Makris, George Marios;Mando, Pablo;Mansell, James;Mantilla, Willam;Maraldo, Maja;Marcou, Yiola;Margenthaler, Julie;Marta, Gustavo;Martel, Karyne;Marti, Covadonga;Martin-Quesada, Ana Isabel;Martos, Tamara;Masannat, Yazan;Masiello, Valeria;Masuda, Norikazu;Mau, Christine I.;Maulik, Shaurav;Meattini, Icro;Meduri, Bruno;Meretoja, Tuomo;Meterissian, Sarkis;Minisini, Alessandro Marco;Misra, Shagun;Montero, Angel;Morgan, Jenna;Migueláñez, Teresa Muñoz;Munzone, Elisabetta;Murawa, Dawid;Namiq, Karez;Sánchez, María Alejandra Naranjo;Narui, Kazutaka;Nguyen, Toan;Nikolic, Dejan;Nikopoulou, Angeliki;O'Neill, Conor;O'Reilly, Seamus;Oikonomou, Ira;Bagge, Roger Olofsson;Ferrando, Amparo Oltra;Papadopoulos, Lazaros;Pascual, Javier;Pasquier, David;Pellegrini, Alice;Peretz-Yablonski, Tamar;Segura, Cristina Pérez;Piñero-Madrona, Antonio;Pogoda, Katarzyna;Popescu, Razvan;Poppe, Matthew;Porpiglia, Mauro;Portik, Daniel;Moura, Jose Fernando Prado;Provenzano, Elena;Puchinskaya, Marina;Putora, Paul Martin;Radhakrishnan, Venkatraman;Rahim, Ishtiaq Ur;Ramiah, Duvern;Rao, Smitha;Ratosa, Ivica;Razis, Evangelia;Read, Rebecca;Rebaza, Lia;Redfern, Andrew;Reinert, Tomas;Retamales, Javier;Riis, Margit;Roberts, Neill;N. Rocco;Rojas, Beatriz;Roshanlall, Chandeena;Rosset, Laurent;Rovera, Francesca;Rubio, Isabel T.;Russell, Nicola;Ruyssers, Natacha;Ryu, Jai Min;Sackey, Helena;Saha, Sunita;Salinas, Jorge Emilio;Sánchez-Méndez, Jose I.;Savva, Constantinos;Scardina, Lorenzo;Serra, Margherita;Setakornnukul, Jiraporn;Shanthilal, Mukesh;Sharawy, Iman;Sharma, Shelly;Shenoy, Shashank;Shetty, Preethi S.;Shoshkova, Mery;Sibbering, Mark;Sidiropoulou, Zacharoula;Silva, Aumilto;Simcock, Richard;Sirohi, Bhawana;Smith, Fiona;Snook, Kylie;De Celis, Enrique Soto Perez;Spanheimer, Philip;Stranzl, Heidi;Stuart, Kirsty;Suga, Yisihak;Susini, Tommaso;Swinden, Michael;Tandon, Megha;Tavoletta, Maria Saveria;Taylor, Donatienne;Liutti, Vitor Teixeira;Tezcanli, Evrim;Thaweerat, Wajana;Thomson, Jacqui;Thorat, Mangesh;Tsiatas, Marinos;Tsoutsou, Pelagia;Tvedskov, Tove;Ueno, Takayuki;Vaidya, Jayant;Valachis, Antonis;Berkmortel, Franchette Van Den;Hage, Jos Van Der;Duijnhoven, Frederieke Van;Van Maaren, Marissa C.;Vandermeulen, Ad;Vázquez-Barreiro, Beatriz;Velu, Umesh;Venkitaraman, Ramachandran;Vidal-Sicart, Sergi;Vohra, Lubna;Voutsadakis, Ioannis;Wadasadawala, Tabassum;Walker, Melanie;Wapnir, Irene;Warnberg, Fredrik;Wiebe, Ericka;Wong, Stephanie;Wyld, Lynda;Kumar, Sanjay;Yeh, Janice;Yiallourou, Anneza;Youn, Hyun Jo;Žatecký, Jan;Cobos, Gastón Zatta;Zeko, Amanda;Zivkovic, Marija;Zope, Anagha

2025

Abstract

Accurate information about locoregional breast cancer treatments following neoadjuvant systemic therapy (NST) is essential for meaningful interpretation of oncological outcomes but reporting is currently poor. We developed a core outcome set (COS) to improve the quality and consistency of locoregional outcome reporting in breast cancer NST trials. The COS was developed in three phases according to COS-STAD guidance, with the generation of a list of relevant outcome domains, prioritisation of outcomes through two rounds of an international online multi-stakeholder Delphi survey and a consensus meeting. 159 unique locoregional outcomes were classified into 101 outcome domains for inclusion in the Delphi survey, which was completed by 470 international professionals. The final 15-item COS, which included the pre-NST surgical plan, details of surgery performed following completion of treatment and details of radiation therapy, was agreed at an in-person consensus meeting. Widespread COS implementation will improve the quality and value of future NST trials.

Scheda breve

Scheda completa

Scheda completa (DC)

	Settori scientifico-disciplinari dell'articolo (validi dal 09/05/2024)
	
				Settore MEDS-06/A - Chirurgia generale
			
	Data di pubblicazione
	
				28-ott-2025
			
	Rivista in ANCE
	
				NPJ BREAST CANCER
			
	DOI
	
				https://dx.doi.org/10.1038/s41523-025-00824-w
			
	Tipologia
	
				Article (author)
			
	Appare nelle tipologie:
	
				01 - Articolo su periodico

File in questo prodotto:

File	Dimensione	Formato
unpaywall-bitstream-672233463.pdf accesso aperto Tipologia: Publisher's version/PDF Licenza: Creative commons Dimensione 718.59 kB Formato Adobe PDF Visualizza/Apri	718.59 kB	Adobe PDF	Visualizza/Apri

Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/1218084

Citazioni

1

0

0

0

IRIS Institutional Research Information System - AIR Archivio Istituzionale della Ricerca