Human biomonitoring (HBM) provides an integrated chemical exposures assessment considering all routes and sources of exposure. The accurate interpretation and comparability of biomarkers of exposure and effect depend on harmonized, quality-assured sampling, processing, and analysis. Currently, the lack of broadly accepted guidance on minimum information required for collecting and reporting HBM data, hinders comparability between studies. Furthermore, it prevents HBM from reaching its full potential as a reliable approach for assessing and managing the risks of human exposure to chemicals. The European Chapter of the International Society of Exposure Science HBM Working Group (ISES Europe HBM working group) has established a global human biomonitoring community network (HBM Global Network) to develop a guidance to define the minimum information to be collected and reported in HBM, called the “Minimum Information Requirements for Human Biomonitoring (MIR-HBM)”. This work builds on previous efforts to harmonize HBM worldwide. The MIR-HBM guidance covers all phases of HBM from the design phase to the effective communication of results. By carefully defining MIR for all phases, researchers and health professionals can make their HBM studies and programs are robust, reproducible, and meaningful. Acceptance and implementation of MIR-HBM Guidelines in both the general population and occupational fields would improve the interpretability and regulatory utility of HBM data. While implementation challenges remain—such as varying local capacities, and ethical and legal differences at the national levels, this initiative represents an important step toward harmonizing HBM practice and supports an ongoing dialogue among policymakers, legal experts, and scientists to effectively address these challenges. Leveraging the data and insights from HBM, policymakers can develop more effective strategies to protect public health and ensure safer working environments.
Guidance on minimum information requirements (MIR) from designing to reporting human biomonitoring (HBM) / M. Zare Jeddi, K.S. Galea, J. Ashley-Martin, J. Nassif, T. Pollock, D. Poddalgoda, K.M. Kasiotis, K. Machera, H.M. Koch, M.E. López, M.K. Chung, J. Kil, K. Jones, A. Covaci, Y. Ait Bamai, M.F. Fernandez, R.P. Kase, H. Louro, M.J. Silva, T. Santonen, A. Katsonouri, A. Castaño, L. Quirós-Alcalá, E.Z. Lin, K. Pollitt, A. Virgolino, P.T.J. Scheepers, L.J. Melnyk, V. Mustieles, A.I. Cañas Portilla, S. Viegas, N. Von Goetz, O. Sepai, E. Bird, T. Göen, S. Fustinoni, M. Ghosh, H. Dirven, J. Kwon, C. Carignan, Y. Mizuno, Y. Ito, Y. Xia, S.F. Nakayama, K.C. Makris, P.J. Parsons, M. Gonzales, M. Bader, M. Dusinska, A. Menouni, R.C. Duca, K. Chbihi, S.E. Jaafari, L. Godderis, A. Van Nieuwenhuyse, A. Qureshi, I. Ali, C.C. Trindade, J.P. Teixeira, A. Bartonova, G. Tranfo, K. Audouze, S. Verpaele, J. Lakind, H. Mol, J. Bessems, B. Magagna, M.N. Waras, A. Connolly, M. Nascarella, W. Yang, P. Huang, J. Lee, H. Heussen, O. Goksel, M. Yunesian, L.W.Y. Yeung, G. Souza, A.M. Vekic, E.N. Haynes, N.B. Hopf. - In: ENVIRONMENT INTERNATIONAL. - ISSN 1873-6750. - 202:(2025 Aug), pp. 109601.1-109601.19. [10.1016/j.envint.2025.109601]
Guidance on minimum information requirements (MIR) from designing to reporting human biomonitoring (HBM)
S. Fustinoni;
2025
Abstract
Human biomonitoring (HBM) provides an integrated chemical exposures assessment considering all routes and sources of exposure. The accurate interpretation and comparability of biomarkers of exposure and effect depend on harmonized, quality-assured sampling, processing, and analysis. Currently, the lack of broadly accepted guidance on minimum information required for collecting and reporting HBM data, hinders comparability between studies. Furthermore, it prevents HBM from reaching its full potential as a reliable approach for assessing and managing the risks of human exposure to chemicals. The European Chapter of the International Society of Exposure Science HBM Working Group (ISES Europe HBM working group) has established a global human biomonitoring community network (HBM Global Network) to develop a guidance to define the minimum information to be collected and reported in HBM, called the “Minimum Information Requirements for Human Biomonitoring (MIR-HBM)”. This work builds on previous efforts to harmonize HBM worldwide. The MIR-HBM guidance covers all phases of HBM from the design phase to the effective communication of results. By carefully defining MIR for all phases, researchers and health professionals can make their HBM studies and programs are robust, reproducible, and meaningful. Acceptance and implementation of MIR-HBM Guidelines in both the general population and occupational fields would improve the interpretability and regulatory utility of HBM data. While implementation challenges remain—such as varying local capacities, and ethical and legal differences at the national levels, this initiative represents an important step toward harmonizing HBM practice and supports an ongoing dialogue among policymakers, legal experts, and scientists to effectively address these challenges. Leveraging the data and insights from HBM, policymakers can develop more effective strategies to protect public health and ensure safer working environments.
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