Hereditary Lobular Breast Cancer Syndrome: Role of Surgery

Hereditary lobular breast cancer is a novel and rare inherited syndrome, and it represents a multifaceted and fascinating clinical entity. In recent years, it has been arousing intense scientific research, actively involving clinicians and researchers specializing in different fields, in order to clearly and precisely outline its specific management, which is currently particularly nuanced and controversial. In this sense, prophylactic and therapeutic surgery plays a significant role in the management of affected women: diversified clinical, genetic, and individual considerations should be contemplated in a multidisciplinary fashion, adhering to available international scientific evidence and guidelines. The chapter offers a surgical perspective on current knowledge of this issue, also reporting a technical and specialized study of preventive mastectomy.