Appropriate treatment approaches and prognosis of pleural mesothelioma

The current standard-of-care treatment of malignant pleural mesothelioma (MPM) is generally accepted as systemic therapy alone. Surgery could be part of a multimodal treatment plan since it is the only modality that could render a patient without the disease. Selecting patients fit for surgery, determining the optimal operation and the additional treatments have not yet been established due to the severe variability of neoplasm itself related to the surgical techniques’ variability. Even though there is an MPM staging system, the results of surgery remain to be strongly affected by other prognosticators (e.g., subtype of histology, not taken by the contemporary staging systems). Consequently, there is not a common denominator that permits careful evaluation between surgical cohorts and the definitive creation of beneficial operational approach.