Paraoxonase (PON) gene polymorphisms have been associated with susceptibility to sporadic amyotrophic lateral sclerosis (ALS). We have investigated the role of the previously associated single nucleotide polymorphisms rs854560, rs662, and rs6954345 in 350 ALS patients and 376 matched controls from Italy. No significant association was observed at genotype and haplotype level. Our data suggest that PON polymorphisms are not involved in ALS pathogenesis in an Italian population.
Lack of association of PON polymorphisms with sporadic ALS in an Italian population / C. Ricci, S. Battistini, L. Cozzi, M. Benigni, P. Origone, L. Verriello, C. Lunetta, C. Cereda, P. Milani, G. Greco, M.C. Patrosso, R. Causarano, C. Caponnetto, F. Giannini, M. Corbo, S. Penco. - In: NEUROBIOLOGY OF AGING. - ISSN 0197-4580. - 32:3(2011), pp. 552.e7.7-552.e7.13. [10.1016/j.neurobiolaging.2010.02.010]
Lack of association of PON polymorphisms with sporadic ALS in an Italian population
C. Cereda;
2011
Abstract
Paraoxonase (PON) gene polymorphisms have been associated with susceptibility to sporadic amyotrophic lateral sclerosis (ALS). We have investigated the role of the previously associated single nucleotide polymorphisms rs854560, rs662, and rs6954345 in 350 ALS patients and 376 matched controls from Italy. No significant association was observed at genotype and haplotype level. Our data suggest that PON polymorphisms are not involved in ALS pathogenesis in an Italian population.
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2011.Ricci Penco.Lack of association of PON polymorphisms with sporadic ALS.NeurobAging.pdf
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